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Table 4 Univariate and multivariable analysis of FFDM

From: The role of neoadjuvant radiochemotherapy in the management of localized high-grade soft tissue sarcoma

Variable All (N = 115) G2 sarcoma (N = 53) G3 sarcoma (N = 62)
Univariate analysis Multivariable analysis Univariate analysis Multivariable analysis Univariate analysis Multivariable analysis
  HR (95% CI) p-Value HR (95% CI) p-Value HR (95% CI) p-Value HR (95% CI) p-Value HR (95% CI) p-Value HR (95% CI) p-Value
Age (in years)  
 < 61 Ref     Ref     Ref    
 ≥ 61 1.137 (.614–2.105) .683    .732 (.186–2.883) .655    1.038 (.507–2.125) .918   
Sex  
 Male Ref     Ref     Ref    
 Female .744 (.399–1.387) .352    1.112 (.323–3.823) .866    .885 (.406–1.926) .757   
KPS  
 < 90 Ref   Ref   Ref     Ref   Ref  
 ≥ 90 .476 (.253-.895) .021* .569 (.298–1.087) .088 2.361 (.488–11.419) .285    .306 (.143-.652) .002* .496 (.219–1.135) .093
Location  
 Other Ref     Ref     Ref    
 Extremity .818 (.415–1.612) .561    1.893 (.399–8.971) .421    .535 (.250–1.143) .106   
Tumor size (in cm)  
 < 8.8 Ref     Ref     Ref    
 ≥ 8.8 1.282 (.686–2.394) .436    .766 (.197–2.977) .700    1.284 (.609–2.704) .511   
Resection margin  
 R0 Ref     Ref     Ref    
 R1/2 1.443 (.510–4.086) .489    2.092 (.417–10.490) .370    1.780 (.415–7.644) .438   
 n/a .624 (.188–2.072) .441    - -    1.724 (.519–5.727) .374   
Therapy  
 Other therapy Ref   Ref   Ref     Ref   Ref  
 Neoadjuvant  RCT .344 (.141-.836) .018* .415 (.166–1.036) .059 .965 (.195–4.767) .965    .182 (.061-.540) .002* .267 (.083-.862) .027*
Hyperthermia  
 No Ref     Ref     Ref    
 Yes 1.890 (.857–4.171 .115    2.510 (.514–12.258) .256    1.800 (.714–4.541) .213   
  1. n/a not available