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Table 3 Univariate and multivariable analysis of OS

From: The role of neoadjuvant radiochemotherapy in the management of localized high-grade soft tissue sarcoma

Variable

All (N = 115)

G2 sarcoma (N = 53)

G3 sarcoma (N = 62)

Univariate analysis

Multivariable analysis

Univariate analysis

Multivariable analysis

Univariate analysis

Multivariable analysis

 

HR (95% CI)

p-Value

HR (95% CI)

p-Value

HR (95% CI)

p-Value

HR (95% CI)

p-Value

HR (95% CI)

p-Value

HR (95% CI)

p-Value

Age (in years)

 

 < 61

Ref

   

Ref

   

Ref

   

 ≥ 61

1.951 (.991–3.842)

.053

  

2.482 (.807–7.636)

.113

  

1.446 (.617–3.387)

.396

  

Sex

 

 Male

Ref

   

Ref

.303

  

Ref

   

 Female

.853 (.442–1.646)

.636

  

.563 (.189–1.680)

   

1.271 (.554–2.915)

.572

  

KPS

 

 < 90

Ref

 

Ref

 

Ref

   

Ref

 

Ref

 

 ≥ 90

.386 (.197-.756)

.006*

.485 (.238-.988)

.046*

.444 (.144–1.365)

.156

  

.372 (.162-.858)

.020*

.577 (.232–1.432)

.236

Location

 

 Other

Ref

   

Ref

 

Ref

 

Ref

   

 Extremity

.532 (.271–1.042)

.066

  

.244 (.078-.761)

.015*

.240 (.066-.867)

.029*

.774 (.305–1.963)

.590

  

Tumor size (in cm)

 

 < 8.8

Ref

   

Ref

   

Ref

   

 ≥ 8.8

1.356 (.707–2.603)

.359

  

1.369 (.459–4.079)

.573

  

1.246 (.545–2.852)

.602

  

Resection margin

 

 R0

Ref

 

Ref

 

Ref

 

Ref

 

Ref

   

 R1/2

3.090 (1.336–7.146)

.008*

2.114 (.884–5.058)

.092

4.648 (1.429–15.113)

.011*

2.252 (.620–8.186)

.218

2.137 (.480–9.512)

.319

  

 n/a

.577 (.137–2.424)

.453

.477 (.113–2.010)

.313

-

-

  

1.561 (.362–6.731)

.550

  

Therapy

 

 Other therapy

Ref

 

Ref

 

Ref

   

Ref

 

Ref

 

 Neoadjuvant RCT

.405 (.165-.994)

.049*

.544 (.212–1.394)

.205

.830 (.182–3.793)

.810

  

.234 (.075-.729)

.012*

.318 (.093–1.090)

.068

Hyperthermia

 

 No

Ref

   

Ref

   

Ref

   

 Yes

1.130 (.433–2.946)

.803

  

1.353 (.295–6.194)

.697

  

1.029 (.296–3.573)

.965

  
  1. n/a not available
  2. * = p < 0.05, statistically significant