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Table 3 Univariate and multivariable analysis of OS

From: The role of neoadjuvant radiochemotherapy in the management of localized high-grade soft tissue sarcoma

Variable All (N = 115) G2 sarcoma (N = 53) G3 sarcoma (N = 62)
Univariate analysis Multivariable analysis Univariate analysis Multivariable analysis Univariate analysis Multivariable analysis
  HR (95% CI) p-Value HR (95% CI) p-Value HR (95% CI) p-Value HR (95% CI) p-Value HR (95% CI) p-Value HR (95% CI) p-Value
Age (in years)  
 < 61 Ref     Ref     Ref    
 ≥ 61 1.951 (.991–3.842) .053    2.482 (.807–7.636) .113    1.446 (.617–3.387) .396   
Sex  
 Male Ref     Ref .303    Ref    
 Female .853 (.442–1.646) .636    .563 (.189–1.680)     1.271 (.554–2.915) .572   
KPS  
 < 90 Ref   Ref   Ref     Ref   Ref  
 ≥ 90 .386 (.197-.756) .006* .485 (.238-.988) .046* .444 (.144–1.365) .156    .372 (.162-.858) .020* .577 (.232–1.432) .236
Location  
 Other Ref     Ref   Ref   Ref    
 Extremity .532 (.271–1.042) .066    .244 (.078-.761) .015* .240 (.066-.867) .029* .774 (.305–1.963) .590   
Tumor size (in cm)  
 < 8.8 Ref     Ref     Ref    
 ≥ 8.8 1.356 (.707–2.603) .359    1.369 (.459–4.079) .573    1.246 (.545–2.852) .602   
Resection margin  
 R0 Ref   Ref   Ref   Ref   Ref    
 R1/2 3.090 (1.336–7.146) .008* 2.114 (.884–5.058) .092 4.648 (1.429–15.113) .011* 2.252 (.620–8.186) .218 2.137 (.480–9.512) .319   
 n/a .577 (.137–2.424) .453 .477 (.113–2.010) .313 - -    1.561 (.362–6.731) .550   
Therapy  
 Other therapy Ref   Ref   Ref     Ref   Ref  
 Neoadjuvant RCT .405 (.165-.994) .049* .544 (.212–1.394) .205 .830 (.182–3.793) .810    .234 (.075-.729) .012* .318 (.093–1.090) .068
Hyperthermia  
 No Ref     Ref     Ref    
 Yes 1.130 (.433–2.946) .803    1.353 (.295–6.194) .697    1.029 (.296–3.573) .965   
  1. n/a not available
  2. * = p < 0.05, statistically significant