Table 2 Univariate and multivariable analysis of LC

Age (in years)

 < 61

Ref

Ref

Ref

 ≥ 61

.881 (.407–1.909)

.749

.584 (.155–2.202)

.427

1.069 (.380–3.009)

.899

Sex

 Male

Ref

Ref

Ref

 Female

.888 (.407–1.934)

.764

.386 (.113–1.318)

.129

1.896 (.686–5.244)

.218

KPS

 < 90

Ref

Ref

Ref

Ref

 ≥ 90

.595 (.275–1.289)

.188

1.249 (.365–4.274)

.724

.330 (.112-.968)

.044*

.622 (.203–1.903)

.405

Location

 Other

Ref

Ref

Ref

Ref

Ref

 Extremity

.262 (.120-.572)

.001*

.300 (.124-.724)

.007*

.151 (.040-.576)

.006*

.293 (.066–1.302)

.107

.363 (.128–1.029)

.057

Tumor size (in cm)

 < 8.8

Ref

Ref

Ref

 ≥ 8.8

1.006 (.459–2.208)

.987

1.873 (.571–6.142)

.300

.580 (.201–1.675)

.314

Resection margin

 R0

Ref

Ref

Ref

Ref

Ref

 R1/2

6.457 (2.738–15.228)

 < .001*

3.303 (1.300–8.396)

.012*

13.434 (3.433–52.567)

 < .001*

7.469 (1.649–33.828)

.009*

2.00 (.258–15.479)

.507

 n/a

1.017 (.234–4.426)

.982

.411 (.086–1.972)

.266

1.640 (.170–15.817)

.669

.950 (.090–10.006)

.966

1.133 (.148–8.685)

.905

Therapy

 Other therapy

Ref

Ref

Ref

Ref

Ref

 Neoadjuvant RCT

.191 (.045-.815)

.025*

.236 (.053–1.044)

.057

.502 (.064–3.935)

.512

.091 (.012-.708)

.022*

.116 (.014-.974)

.047*

Hyperthermia

 No

Ref

Ref

Ref

 Yes

2.245 (.888–5.674)

.087

2.982 (.780–11.396)

.110

2.071 (.554–7.748)

.279