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Table 2 Univariate and multivariable analysis of LC

From: The role of neoadjuvant radiochemotherapy in the management of localized high-grade soft tissue sarcoma

Variable All (N = 115) G2 sarcoma (N = 53) G3 sarcoma (N = 62)
Univariate analysis Multivariable analysis Univariate analysis Multivariable analysis Univariate analysis Multivariable analysis
  HR (95% CI) p-Value HR (95% CI) p-Value HR (95% CI) p-Value HR (95% CI) p-Value HR (95% CI) p-Value HR (95% CI) p-Value
Age (in years)  
 < 61 Ref     Ref     Ref    
 ≥ 61 .881 (.407–1.909) .749    .584 (.155–2.202) .427    1.069 (.380–3.009) .899   
Sex  
 Male Ref     Ref     Ref    
 Female .888 (.407–1.934) .764    .386 (.113–1.318) .129    1.896 (.686–5.244) .218   
KPS  
 < 90 Ref     Ref     Ref   Ref  
 ≥ 90 .595 (.275–1.289) .188    1.249 (.365–4.274) .724    .330 (.112-.968) .044* .622 (.203–1.903) .405
Location  
 Other Ref   Ref   Ref   Ref   Ref    
 Extremity .262 (.120-.572) .001* .300 (.124-.724) .007* .151 (.040-.576) .006* .293 (.066–1.302) .107 .363 (.128–1.029) .057   
Tumor size (in cm)  
 < 8.8 Ref     Ref     Ref    
 ≥ 8.8 1.006 (.459–2.208) .987    1.873 (.571–6.142) .300    .580 (.201–1.675) .314   
Resection margin  
 R0 Ref   Ref   Ref   Ref   Ref    
 R1/2 6.457 (2.738–15.228)  < .001* 3.303 (1.300–8.396) .012* 13.434 (3.433–52.567)  < .001* 7.469 (1.649–33.828) .009* 2.00 (.258–15.479) .507   
 n/a 1.017 (.234–4.426) .982 .411 (.086–1.972) .266 1.640 (.170–15.817) .669 .950 (.090–10.006) .966 1.133 (.148–8.685) .905   
Therapy  
 Other therapy Ref   Ref   Ref     Ref   Ref  
 Neoadjuvant RCT .191 (.045-.815) .025* .236 (.053–1.044) .057 .502 (.064–3.935) .512    .091 (.012-.708) .022* .116 (.014-.974) .047*
Hyperthermia  
 No Ref     Ref     Ref    
 Yes 2.245 (.888–5.674) .087    2.982 (.780–11.396) .110    2.071 (.554–7.748) .279   
  1. n/a not available