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Table 1 Baseline characteristics

From: The role of neoadjuvant radiochemotherapy in the management of localized high-grade soft tissue sarcoma

Characteristic

Total

(N = 115)

(%)

Neoadjuvant RCT

(N = 23)

(%)

Other therapies

(N = 92)

(%)

Sex

 Male

62

53.9

13

56.5

49

53.3

 Female

53

46.1

10

43.5

43

46.7

Mean age, years (range)

59.27 (20–95)

 

52.7 (23–74)

 

60.91 (20–95)

 

Karnofsky Performance Status

 40

1

0.9

0

0

1

1.1

 50

0

0

0

0

0

0

 60

4

3.5

0

0

4

4.3

 70

4

3.5

0

0

4

4.3

 80

36

31.3

5

21.7

31

33.7

 90

56

48.7

13

56.5

43

46.7

 100

13

11.3

5

21.7

8

8.7

 n/a

1

0.9

0

0

1

1.1

Anatomic location

 Upper extremity

10

8.7

0

0

10

10.9

 Lower extremity

66

57.4

18

78.3

48

52.2

 Pelvis

6

5.2

3

13

3

3.3

 Head/neck

6

5.2

0

0

6

6.5

 Trunk wall

15

13

1

4.3

14

15.2

 Retroperitoneal

8

7

1

4.3

7

7.6

 Intra-abdominal

4

3.5

0

0

4

4.3

Sarcoma Subtype

Liposarcoma/Myxoid Liposarcoma

25

21.7

1

4.3

24

26.1

Myxofibrosarcoma

26

22.6

6

26.1

20

21.7

Undifferentiated pleomorphic sarcoma

21

18.3

5

21.7

16

17.4

Synovial cell sarcoma

12

10.4

5

21.7

7

7.6

Malignant peripheral nerve sheath tumor

8

7

1

4.3

7

7.6

Leiomyosarcoma

9

7.8

1

4.3

8

8.7

Angiosarcoma

5

4.3

2

8.7

3

3.3

Spindle cell sarcoma

3

2.6

0

0

3

3.3

Fibrosarcoma

1

0.9

0

0

1

1.1

 Giant cell sarcoma

1

0.9

0

0

1

1.1

 Small cell/Clear cell sarcoma

2

1.7

1

4.3

1

1.1

 Epitheloid sarcoma

1

0.9

1

4.3

0

0

 Myxoinflammatory fibroblastic sarcoma

1

0.9

0

0

1

1.1

Mean tumor size, cm (range)

10.63 (1.5–41.6)

 

10.35 (3.5–16)

 

10.71 (1.5–41.6)

 

Tumor depth

 Superficial

14

12.2

2

8.7

12

13

 Deep

85

73.9

20

87

65

70.7

 n/a

16

13.9

1

4.3

14

15.2

Grade

 G2

53

46.1

8

34.8

45

48.9

 G3

62

53.9

15

65.2

47

51.1

Resection margin

 R0

92

80

21

91.3

71

77.2

 R1

10

8.7

1

4.3

9

9.8

 R2

2

1.7

0

0

2

2.2

 n/a

11

9.6

1

4.3

10

10.9

Mean single radiation dose, Gy (range)

2.1 (1.2–5.0)

 

1.9 (1.6–2.15)

 

2.13 (1.2–5.0)

 

Mean total radiation dose, Gy (range)

58.4 (25.0–75.7)

 

54.1 (48.8–60.2)

 

59.5 (25.0–75.7)

 

Targeted therapy

1

0.9

0

0

1

1.1

Hyperthermia

22

19.1

2

8.7

20

21.7

Local recurrence/progress

27

23.5

2

8.7

25

27.2

Therapy local recurrence

 Resection

20

17.4

2

8.7

18

19.6

 Radiotherapy

4

3.5

0

0

5

5.4

 Chemotherapy

11

9.6

0

0

11

12

 Targeted Therapy

2

1.7

0

0

2

2.2

 Hyperthermia

3

2.6

0

0

3

3.3

Distant metastases

42

36.5

6

26.1

36

39.1

 Lungs

33

28.7

5

21.7

28

30.4

 Bones

3

2.6

0

0

3

3.3

 Liver

4

3.5

0

0

4

4.3

 Lymph nodes

2

1.7

1

4.3

1

1.1

 Other

7

6.1

0

0

7

7.6

Therapy distant metastases

 Resection

20

17.4

5

21.7

15

16.3

 Radiotherapy

9

7.8

1

4.3

8

8.7

 Chemotherapy

16

13.9

1

4.3

15

16.3

 Targeted Therapy

1

0.9

0

0

1

1.1

 Hyperthermia

2

1.7

0

0

2

2.2

Death

37

32.2

6

26.1

31

33.7

  1. n/a not available