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Table 1 Baseline characteristics

From: The role of neoadjuvant radiochemotherapy in the management of localized high-grade soft tissue sarcoma

Characteristic Total
(N = 115)
(%) Neoadjuvant RCT
(N = 23)
(%) Other therapies
(N = 92)
(%)
Sex
 Male 62 53.9 13 56.5 49 53.3
 Female 53 46.1 10 43.5 43 46.7
Mean age, years (range) 59.27 (20–95)   52.7 (23–74)   60.91 (20–95)  
Karnofsky Performance Status
 40 1 0.9 0 0 1 1.1
 50 0 0 0 0 0 0
 60 4 3.5 0 0 4 4.3
 70 4 3.5 0 0 4 4.3
 80 36 31.3 5 21.7 31 33.7
 90 56 48.7 13 56.5 43 46.7
 100 13 11.3 5 21.7 8 8.7
 n/a 1 0.9 0 0 1 1.1
Anatomic location
 Upper extremity 10 8.7 0 0 10 10.9
 Lower extremity 66 57.4 18 78.3 48 52.2
 Pelvis 6 5.2 3 13 3 3.3
 Head/neck 6 5.2 0 0 6 6.5
 Trunk wall 15 13 1 4.3 14 15.2
 Retroperitoneal 8 7 1 4.3 7 7.6
 Intra-abdominal 4 3.5 0 0 4 4.3
Sarcoma Subtype
Liposarcoma/Myxoid Liposarcoma 25 21.7 1 4.3 24 26.1
Myxofibrosarcoma 26 22.6 6 26.1 20 21.7
Undifferentiated pleomorphic sarcoma 21 18.3 5 21.7 16 17.4
Synovial cell sarcoma 12 10.4 5 21.7 7 7.6
Malignant peripheral nerve sheath tumor 8 7 1 4.3 7 7.6
Leiomyosarcoma 9 7.8 1 4.3 8 8.7
Angiosarcoma 5 4.3 2 8.7 3 3.3
Spindle cell sarcoma 3 2.6 0 0 3 3.3
Fibrosarcoma 1 0.9 0 0 1 1.1
 Giant cell sarcoma 1 0.9 0 0 1 1.1
 Small cell/Clear cell sarcoma 2 1.7 1 4.3 1 1.1
 Epitheloid sarcoma 1 0.9 1 4.3 0 0
 Myxoinflammatory fibroblastic sarcoma 1 0.9 0 0 1 1.1
Mean tumor size, cm (range) 10.63 (1.5–41.6)   10.35 (3.5–16)   10.71 (1.5–41.6)  
Tumor depth
 Superficial 14 12.2 2 8.7 12 13
 Deep 85 73.9 20 87 65 70.7
 n/a 16 13.9 1 4.3 14 15.2
Grade
 G2 53 46.1 8 34.8 45 48.9
 G3 62 53.9 15 65.2 47 51.1
Resection margin
 R0 92 80 21 91.3 71 77.2
 R1 10 8.7 1 4.3 9 9.8
 R2 2 1.7 0 0 2 2.2
 n/a 11 9.6 1 4.3 10 10.9
Mean single radiation dose, Gy (range) 2.1 (1.2–5.0)   1.9 (1.6–2.15)   2.13 (1.2–5.0)  
Mean total radiation dose, Gy (range) 58.4 (25.0–75.7)   54.1 (48.8–60.2)   59.5 (25.0–75.7)  
Targeted therapy 1 0.9 0 0 1 1.1
Hyperthermia 22 19.1 2 8.7 20 21.7
Local recurrence/progress 27 23.5 2 8.7 25 27.2
Therapy local recurrence
 Resection 20 17.4 2 8.7 18 19.6
 Radiotherapy 4 3.5 0 0 5 5.4
 Chemotherapy 11 9.6 0 0 11 12
 Targeted Therapy 2 1.7 0 0 2 2.2
 Hyperthermia 3 2.6 0 0 3 3.3
Distant metastases 42 36.5 6 26.1 36 39.1
 Lungs 33 28.7 5 21.7 28 30.4
 Bones 3 2.6 0 0 3 3.3
 Liver 4 3.5 0 0 4 4.3
 Lymph nodes 2 1.7 1 4.3 1 1.1
 Other 7 6.1 0 0 7 7.6
Therapy distant metastases
 Resection 20 17.4 5 21.7 15 16.3
 Radiotherapy 9 7.8 1 4.3 8 8.7
 Chemotherapy 16 13.9 1 4.3 15 16.3
 Targeted Therapy 1 0.9 0 0 1 1.1
 Hyperthermia 2 1.7 0 0 2 2.2
Death 37 32.2 6 26.1 31 33.7
  1. n/a not available