Efficacy of concurrent chemoradiotherapy plus Endostar compared with concurrent chemoradiotherapy in the treatment of locally advanced nasopharyngeal carcinoma: a retrospective study

Table 6 Late toxic reactions

Adverse event	CCRT + E (n = 43)			CCRT (n = 45)			P value for events Grade 1 and 2	P value for events Grade 3 and 4
Adverse event	1 + 2	3	4	1 + 2	3	4	P value for events Grade 1 and 2	P value for events Grade 3 and 4
Limitation of mouth opening	1 (2.3)	0 (0)	0 (0)	1 (2.2)	0 (0)	0 (0)	1.000	–
Decreased vision	1 (2.3)	0 (0)	0 (0)	2 (4.4)	0 (0)	0 (0)	1.000	–
Hearing loss	6 (14.0)	0 (0)	0 (0)	6 (13.3)	2 (4.4)	0 (0)	0.932	0.495
Temporal lobe necrosis	1 (2.3)	0 (0)	0 (0)	1 (2.2)	0 (0)	0 (0)	1.000	–
Subcutaneous fibrosis	1 (2.3)	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)	0.489	–
Dry mouth	5 (11.6)	0 (0)	0 (0)	3 (6.7)	0 (0)	0 (0)	0.661	–
Cranial nerve palsy	3 (7.0)	0 (0)	0 (0)	2 (4.4)	0 (0)	0 (0)	0.958	–
Cardiac dysfunction	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)	–	–

ISSN: 1748-717X