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Table 5 Acute toxic reactions

From: Efficacy of concurrent chemoradiotherapy plus Endostar compared with concurrent chemoradiotherapy in the treatment of locally advanced nasopharyngeal carcinoma: a retrospective study

Adverse event CCRT + E
(n = 43)
CCRT
(n = 45)
P value for events
Grade 1 and 2
P value for events
Grade 3 and 4
1 + 2 3 4 1 + 2 3 4
Leucopenia 28 (65.1) 14 (32.6) 0 (0) 34 (75.6) 5 (11.1) 1 (2.2) 0.283 0.031
Thrombocytopenia 8 (18.6) 2 (4.7) 0 (0) 4 (8.9) 0 (0) 0 (0) 0.309 0.236
Hemoglobin decrease 26 (60.5) 3 (7.0) 0 (0) 22 (48.9) 1 (2.2) 0 (0) 0.276 0.355
Weight loss 30 (69.8) 0 (0) 0 (0) 36 (80.0) 0 (0) 0 (0) 0.268
Nausea 38 (88.4) 1 (2.3) 0 (0) 41 (91.1) 1 (2.2) 0 (0) 0.943 1.000
Vomiting 29 (67.4) 2 (4.7) 0 (0) 34 (75.6) 2 (4.4) 0 (0) 0.399 1.000
Dry mouth 43 (100.0) 0 (0) 0 (0) 42 (93.3) 2 (4.4) 0 (0) 0.242 0.495
Diarrhea 3 (7.0) 0 (0) 0 (0) 2 (4.4) 0 (0) 0 (0) 0.958
Constipation 12 (27.9) 0 (0) 0 (0) 11 (24.4) 0 (0) 0 (0) 0.712
Oral mucositis 39 (90.7) 1 (2.3) 0 (0) 41 (91.1) 2 (4.4) 0 (0) 1.000 1.000
Dermatitis 40 (93.0) 2 (4.7) 0 (0) 42 (93.3) 1 (2.2) 0 (0) 1.000 0.612
Liver dysfunction 13 (30.2) 0 (0) 0 (0) 11 (24.4) 0 (0) 0 (0) 0.542
Renal dysfunction 13 (30.2) 0 (0) 0 (0) 9 (20.0) 0 (0) 0 (0) 0.268
Cardiac dysfunction 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0)
  1. Data are n (%)