Efficacy of concurrent chemoradiotherapy plus Endostar compared with concurrent chemoradiotherapy in the treatment of locally advanced nasopharyngeal carcinoma: a retrospective study

Table 5 Acute toxic reactions

Adverse event	CCRT + E (n = 43)			CCRT (n = 45)			P value for events Grade 1 and 2	P value for events Grade 3 and 4
Adverse event	1 + 2	3	4	1 + 2	3	4	P value for events Grade 1 and 2	P value for events Grade 3 and 4
Leucopenia	28 (65.1)	14 (32.6)	0 (0)	34 (75.6)	5 (11.1)	1 (2.2)	0.283	0.031
Thrombocytopenia	8 (18.6)	2 (4.7)	0 (0)	4 (8.9)	0 (0)	0 (0)	0.309	0.236
Hemoglobin decrease	26 (60.5)	3 (7.0)	0 (0)	22 (48.9)	1 (2.2)	0 (0)	0.276	0.355
Weight loss	30 (69.8)	0 (0)	0 (0)	36 (80.0)	0 (0)	0 (0)	0.268	–
Nausea	38 (88.4)	1 (2.3)	0 (0)	41 (91.1)	1 (2.2)	0 (0)	0.943	1.000
Vomiting	29 (67.4)	2 (4.7)	0 (0)	34 (75.6)	2 (4.4)	0 (0)	0.399	1.000
Dry mouth	43 (100.0)	0 (0)	0 (0)	42 (93.3)	2 (4.4)	0 (0)	0.242	0.495
Diarrhea	3 (7.0)	0 (0)	0 (0)	2 (4.4)	0 (0)	0 (0)	0.958	–
Constipation	12 (27.9)	0 (0)	0 (0)	11 (24.4)	0 (0)	0 (0)	0.712	–
Oral mucositis	39 (90.7)	1 (2.3)	0 (0)	41 (91.1)	2 (4.4)	0 (0)	1.000	1.000
Dermatitis	40 (93.0)	2 (4.7)	0 (0)	42 (93.3)	1 (2.2)	0 (0)	1.000	0.612
Liver dysfunction	13 (30.2)	0 (0)	0 (0)	11 (24.4)	0 (0)	0 (0)	0.542	–
Renal dysfunction	13 (30.2)	0 (0)	0 (0)	9 (20.0)	0 (0)	0 (0)	0.268	–
Cardiac dysfunction	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)	–	–

ISSN: 1748-717X