| OS | PFS | BMFS (in non-BM and non-PCI) | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Univariate analyses | Multivariate analyses | Univariate analyses | Multivariate analyses | Univariate analyses | |||||||||||
P | HR | (95% CI) | P | HR | (95% CI) | P | HR | (95% CI) | P | HR | (95% CI) | P | HR | (95% CI) | |
Gender | 0.542 | 1.226 | 0.638–2.355 |  |  |  | 0.754 | 0.896 | 0.452–1.776 |  |  |  | 0.140 | 0.224 | 0.031–1.631 |
Age | 0.867 | 1.002 | 0.980–1.025 |  |  |  | 0.525 | 0.993 | 0.972–1.015 |  |  |  | 0.519 | 0.988 | 0.954–1.024 |
sTIL | 0.041 | 0.675 | 0.463–0.984 | 0.027 | 0.648 | 0.441–0.951 | 0.020 | 0.637 | 0.436–0.931 | 0.019 | 0.632 | 0.430–0.927 | 0.029 | 0.477 | 0.245–0.927 |
Clinical T stage | 0.288 | 0.896 | 0.732–1.097 |  |  |  | 0.293 | 1.112 | 0.912–1.355 |  |  |  | 0.995 | 0.999 | 0.726–1.375 |
Dmax-T | 0.227 | 1.046 | 0.973–1.125 |  |  |  | 0.016 | 1.087 | 1.016–1.163 |  |  |  | 0.783 | 1.017 | 0.904–1.142 |
Clinical N stage | 0.014 | 1.355 | 1.064–1.724 |  |  |  | 0.012 | 1.347 | 1.069–1.699 | 0.027 | 1.298 | 1.030–1.635 | 0.218 | 1.292 | 0.860–1.940 |
Clinical M stage | 0.000 | 2.153 | 1.469–3.156 | 0.025 | 1.695 | 1.069–2.688 | 0.000 | 2.128 | 1.436–3.153 | 0.001 | 1.960 | 1.306–2.941 | 0.572 | 0.810 | 0.390–1.683 |
Clinical TNM stage | 0.001 | 1.901 | 1.315–2.749 |  |  |  | 0.000 | 1.984 | 1.371–2.869 |  |  |  | 0.595 | 0.845 | 0.455–1.570 |
Regimen of CT | 0.582 | 0.951 | 0.794–1.138 |  |  |  | 0.158 | 1.121 | 0.956–1.315 |  |  |  | 0.519 | 0.903 | 0.663–1.230 |
Cycles of CT | 0.007 | 0.831 | 0.727–0.950 | 0.019 | 0.835 | 0.718–0.971 | 0.352 | 0.939 | 0.822–1.072 |  |  |  | 0.229 | 1.168 | 0.907–1.503 |
TRT | 0.000 | 0.294 | 0.195–0.445 |  |  |  | 0.000 | 0.493 | 0.333–0.730 |  |  |  | 0.370 | 1.390 | 0.676–2.855 |
Dose of TRT | 0.085 | 1.000 | 0.999–1.000 |  |  |  | 0.412 | 1.000 | 1.000–1.001 |  |  |  | 0.421 | 1.000 | 1.000–1.001 |
PCI | 0.052 | 0.408 | 0.165–1.008 |  |  |  | 0.029 | 0.361 | 0.145–0.900 |  |  |  | NA |  |  |
Response to CT | 0.003 | 1.736 | 1.203–2.507 |  |  |  | 0.004 | 1.788 | 1.209–2.647 | 0.040 | 1.514 | 1.018–2.25 | 0.605 | 0.797 | 0.337–1.886 |
Response to TRT | 0.000 | 1.176 | 1.115–1.240 | 0.000 | 1.123 | 1.055–1.196 | 0.000 | 1.100 | 1.046–1.157 |  |  |  | 0.470 | 0.967 | 0.883–1.059 |