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Table 3 Prognostic factors by univariate and multivariate analyses for OS, PFS and BMFS

From: Clinical significance of tumor-infiltrating lymphocytes investigated using routine H&E slides in small cell lung cancer

 

OS

PFS

BMFS (in non-BM and non-PCI)

Univariate analyses

Multivariate analyses

Univariate analyses

Multivariate analyses

Univariate analyses

P

HR

(95% CI)

P

HR

(95% CI)

P

HR

(95% CI)

P

HR

(95% CI)

P

HR

(95% CI)

Gender

0.542

1.226

0.638–2.355

   

0.754

0.896

0.452–1.776

   

0.140

0.224

0.031–1.631

Age

0.867

1.002

0.980–1.025

   

0.525

0.993

0.972–1.015

   

0.519

0.988

0.954–1.024

sTIL

0.041

0.675

0.463–0.984

0.027

0.648

0.441–0.951

0.020

0.637

0.436–0.931

0.019

0.632

0.430–0.927

0.029

0.477

0.245–0.927

Clinical T stage

0.288

0.896

0.732–1.097

   

0.293

1.112

0.912–1.355

   

0.995

0.999

0.726–1.375

Dmax-T

0.227

1.046

0.973–1.125

   

0.016

1.087

1.016–1.163

   

0.783

1.017

0.904–1.142

Clinical N stage

0.014

1.355

1.064–1.724

   

0.012

1.347

1.069–1.699

0.027

1.298

1.030–1.635

0.218

1.292

0.860–1.940

Clinical M stage

0.000

2.153

1.469–3.156

0.025

1.695

1.069–2.688

0.000

2.128

1.436–3.153

0.001

1.960

1.306–2.941

0.572

0.810

0.390–1.683

Clinical TNM stage

0.001

1.901

1.315–2.749

   

0.000

1.984

1.371–2.869

   

0.595

0.845

0.455–1.570

Regimen of CT

0.582

0.951

0.794–1.138

   

0.158

1.121

0.956–1.315

   

0.519

0.903

0.663–1.230

Cycles of CT

0.007

0.831

0.727–0.950

0.019

0.835

0.718–0.971

0.352

0.939

0.822–1.072

   

0.229

1.168

0.907–1.503

TRT

0.000

0.294

0.195–0.445

   

0.000

0.493

0.333–0.730

   

0.370

1.390

0.676–2.855

Dose of TRT

0.085

1.000

0.999–1.000

   

0.412

1.000

1.000–1.001

   

0.421

1.000

1.000–1.001

PCI

0.052

0.408

0.165–1.008

   

0.029

0.361

0.145–0.900

   

NA

  

Response to CT

0.003

1.736

1.203–2.507

   

0.004

1.788

1.209–2.647

0.040

1.514

1.018–2.25

0.605

0.797

0.337–1.886

Response to TRT

0.000

1.176

1.115–1.240

0.000

1.123

1.055–1.196

0.000

1.100

1.046–1.157

   

0.470

0.967

0.883–1.059