Tumor responses to hypofractionated stereotactic radiotherapy combined with whole brain radiotherapy. Plane A shows the best response of patients evaluated by the RECIST 1.1 criteria. Plane B shows the best response of patients evaluated by the RANO-BM criteria. The bars indicate the best percent change in target tumor burden from baseline. Letter A denotes a patient with a > 20% increase in the sum of the longest diameters of target lesions, but the absolute value of the diameter increase was only 3 mm; therefore, the efficacy assessment remains as SD. Letter C denotes a patient who was suspected to have a new intracranial lesion, but the lesion was < 10 mm in diameter on consecutive reexaminations and were assessed as SD. The letters B, D, and F indicate three patients with different numbers of target lesions in the two evaluation criteria, who had the same evaluation results. The letter E indicates a patient with different numbers of target lesions in the two evaluation criteria, which resulted in different evaluation results. The letter G denotes a patient with reduced target lesions but multiple new intracranial lesions. Plane C shows the intracranial progression-free survival of the 27 patients.