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Fig. 4 | Radiation Oncology

Fig. 4

From: Ways to unravel the clinical potential of carbon ions for head and neck cancer reirradiation: dosimetric comparison and local failure pattern analysis as part of the prospective randomized CARE trial

Fig. 4

69-year-old female patient with recurrent oral cavity cancer treated with 51 Gy (RBE) CIRT (A) around 28 years after prior radiotherapy with 75 Gy. CIRT yielded significant clinical benefits w.r.t. the brainstem (− 47.5% Dmax), ipsilateral optic nerve (− 16.8% Dmax), ipsilateral eye (− 21.3% Dmean) and contralateral inner ear (− 23.2% Dmean) compared to VMAT (B). The patient developed type A local failure, delineated on the planning CT (A), caused biological and/or dosimetric failure. Dose recalculation with the modified microdosimetric model w.r.t. the type A failure revealed significantly reduced rGTV Dmean and rGTV D95% dose EQD2 compared to the local effect model I (C–D)

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Radiation Oncology

ISSN: 1748-717X

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