Table 3 Clinical features of all included studies
Study | Type of disease | Histology | Grading | Tumor status P/R/M | Tumor site | Median target volume (cc) |
|---|---|---|---|---|---|---|
Shiba 2021 [10] | Bone Sarcoma | Chordoma = 32; Chondrosarcoma = 9; UPS = 3 Osteosarcoma = 8; SEF = 1 | NR | NR | Pelvis = 49; Axis = 4 | 215.6 (1.6–2074.3) |
Mohamad 2018 [11] | Bone Sarcoma | Osteosarcoma = 26 | NR | 22*/1/3 | Pelvic = 24; Axis = 2 | 452 (172–1774) |
Imai et al. 2017 [12] | Bone Sarcoma | Chondrosarcomas = 73 | G1 = 14; G2 = 51; G3 = 4 Dedifferentiated = 4 | 55/17/1 | Pelvic = 38; Axis = 35 | 471 (25–2900) |
Imai 2016 [13] | Bone Sarcoma | Chordoma = 188 | NR | 188/0/0 | Sacral | 345 (42–1497) |
Matsunobu 2012 [14] | Bone Sarcoma | Osteosarcoma = 78 | NR | 74**/4/0 | Spine/Paraspinal = 15 Pelvic = 61; Others = 2 | 510 (60–2299) |
Imai 2011 [15] | Bone Sarcoma | Chordoma = 95 | NR | 84/11/0 | Sacral | 370 (47–1468) |
Mizoe 2009 [16] | Bone Sarcoma | Chordoma = 33 | NR | NR | Skull base | 32 (2–328) |
Mattke 2018 [17] | Bone Sarcoma | Chondrosarcoma = 79 | G1 or G2 | 70/9/0 | Skull base | 34.6 (8–133) |
Uhl 2014 [18] | Bone Sarcoma | Chordoma = 155 | NR | 101/54/0 | Skull base | 70 (2–294) |
Uhl 2014 [19] | Bone Sarcoma | Chondrosarcoma = 79 | G1 = 51; G1-2 = 7; G2 = 20; G3 = 1 | 54/25/0 | Skull base | 60.5 (3–254.4) |
Combs 2009 [20] | Bone Sarcoma | Chordoma = 7; Chondrosarcoma = 10 | NR | 14/3/0 | Skull base | 73.2 (20.1–182) |
Wu 2019 [21] | Bone Sarcoma | Chordoma = 16; Chondrosarcoma = 5 | NR | 8/13/0 | Extracranial = 21 | 512.7 (142.6–2893) |