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Table 2 Univariate and multivariate cox proportional hazards regression analysis of potential risk factors for endpoints

From: Prognostic significance of MRI-based late-course tumor volume in locoregionally advanced nasopharyngeal carcinoma

Variables

Category

Univariate

Multivariate

  

LRFS

DFS

OS

LRFS

DFS

OS

  

HR

95%CI

P

HR

95%CI

P

HR

95%CI

P

HR

95%CI

P

HR

95%CI

P

HR

95%CI

P

Age

< 55 versus ≥ 55

1.383

0.515–3.718

0.518

1.008

0.550–1.848

0.978

0.981

0.479–2.010

0.958

Gender

Male versus female

2.248

0.511–9.983

0.270

2.365

0.929–6.019

0.061

1.523

0.583–3.982

0.384

T

1,2 versus 3,4

0.350

0.121–1.010

0.042

0.528

0.285–0.979

0.038

0.504

0.239–1.062

0.065

N

0,1 versus 2,3

0.727

0.165–3.210

0.672

0.868

0.365–2.063

0.747

1.057

0.429–2.606

0.903

TNM

III versus IVA

0.588

0.204–1.696

0.320

0.393

0.210–0.735

0.002

0.387

0.185–0.811

0.009

Vpre

> 6.8 cm3 versus ≤ 6.8 cm3

6.613

2.378–18.394

< 0.001

3.910

2.121–7.210

< 0.001

4.463

2.166–9.198

< 0.001

3.910

2.121–7.210

< 0.001

4.463

2.166–9.198

< 0.001

LCV

> 16.3 cm3 versus ≤ 16.3 cm3

7.796

2.694–22.559

< 0.001

2.840

1.543–5.225

< 0.001

2.684

1.298–5.547

0.005

7.796

2.694–22.559

< 0.001

VRR

> 75.1% versus ≤ 75.1%

0.121

0.016–0.913

0.014

0.755

0.386–1.476

0.403

0.643

0.286–1.449

0.281

  1. Vpre tumor volume before treatment, LCV late-course volume, VRR volume regression rate, LRFS local recurrence-free survival, DFS disease-free survival, OS overall survival, HR hazard ratio from Cox hazards model, CI confidence interval; P Value indicates the difference in the c-indexes. The following parameters were included in the models as covariates for each analysis: age, gender, T category, N category, TNM staging, Vpre, LCV and VRR