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Table 4 Treatment and dosimetric parameters reported in selected studies comparing VMAT and DCAT SIMT SRS techniques for multiple brain metastases

From: Single-isocenter multiple-target stereotactic radiosurgery for multiple brain metastases: dosimetric evaluation of two automated treatment planning systems

Parameter Current study Gavaert et al. [22] Hoffmaier et al. [23] Ruggeri et al. [24] Liu et al. [25]
No of patients 36 10 20 20 30
No of lesions 367 40 66 97 217
Median number of lesions for patient 9 (2–25)   3 (2–6) 5 (2–10) 7.5 (4–10)
Median SRS (dose/fraction) 20 Gy, SF 20 Gy, SF 19 Gy, SF 18–27 Gy, 1–3 fr 14–24 Gy, SF
Median PTV (cm3) 0.32 (0.17–1.18) 3.15 (0.14–24.61) 0.8 (0.1–11.9) 2 (0.1–18.6) 0.35 (0.014–17.73)
Median total PTV (cm3) 3.42 (0.61–9.37) 10.6 (0.6–28.66) NR 9.6 (0.5–29) 7.05 (0.49–27.32)
PTV Dmax/D2% < 135% of PD < 125% of PD < 125% of PD < 150% of PD < 175% of PD
PTV Dmin/D98% > 98% > 99.5% > 98% > 98% NR
Mean target coverage VMAT 99.1% ± 2.4%
DCAT 98.9 ± 2.9%
NR NR VMAT 98.2% ± 2.9%
DCAT 96.4 ± 3.5%
VMAT 96.9% ± 2.5%
DCAT 97.5 ± 2.3%
Median conformity index VMAT 0.6 (0.46–0.85)
DCAT 0.75 (0.52–0.86)
VMAT 0.67 ± 0.16*
DCAT 0.65 ± 0.08*
VMAT 0.73 (0.38–0.88)
DCAT 0.75 (0.58–0.89)
VMAT 0.94 (0.85–1.00)*
DCAT 0.75 (0.4–0.96)*
VMAT 0.77 ± 0.12
DCAT 0.7 ± 0.1
Median gradient index VMAT 5.61 (3.64–8.37)
DCAT 4.54 (3.45–7.13)
VMAT 7.1 ± 3.1*
DCAT 3.9 ± 1.4*
VMAT 7.17 (3.35–33.0)
DCAT 5.99 (3.5–15.73)
VMAT 4.17 (3.32–7.46)*
DCAT 4.31 (3.29–5.79)*
NR
Median brain dose VMAT 2.74 (0.55 -5.85)
DCAT 2.37 (0.65–5.62)
NR NR VMAT 2.99 (0.76 -6.17)*
DCAT 3.22 (0.85–7.34)*
VMAT 2.76
DCAT 2.57
Median total V12Gy VMAT 18.51 (2.2–62.3)
DCAT 13.65 (1.87–45.9)
VMAT 46.3 ± 35.9*
DCAT 36.3 ± 27.1*
VMAT 3.1 (0.5–13.9)
DCAT 2.1 (0.1–13.1)
VMAT 23.7 (1.7–86.6)*
DCAT 37.3 (3.2–157.5)*
VMAT 19.2
DCAT 23.7
  1. DCAT Dynamic Conformal Arc Therapy, VMAT Volumetric Target Volume, SIMT Single-isocenter multi-targets, SRS Stereotactic Radiosurgery, PTV Planning Target Volume, PTV D2% and D98% dose received by 2% and 98% of PTV, SF Single Fraction, V12 Gy doses of 12 Gy received by healthy brain (brain-gross tumor volume)
  2. *value are reported as mean