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Table 3 Brain dose and V12Gy, V10Gy, V8Gy, and V5 Gy among DCAT and VMAT plans with 1–10 or > 10 lesions

From: Single-isocenter multiple-target stereotactic radiosurgery for multiple brain metastases: dosimetric evaluation of two automated treatment planning systems

Parameter DCAT VMAT p DCAT VMAT p
1–10 lesions 1–10 lesions > 10 lesions > 10 lesions
Brain dose    0.003    0.001
Mean dose (SD) 1.7 (0.6) 1.88 (0.8)   2.64 (1.3) 3.01 (1.5)  
Median dose (SD) 1.63 1.77   2.3 2.7  
Range 0.65–3.0 0.55–3.48   0.65–5.62 0.55–5.85  
V12Gy    0.0001    0.001
Mean (SD) 7.7 (5.0) 10.5 (6.8)   25.8 (10.6) 39.7 (13.7)  
Median 6.2 8.2   22.7 38.7  
Range 1.87–18.1 2.2–26.4   12.2–45.9 21.9–62.3  
V10Gy    0.0005    0.001
Mean (SD) 10.9 (7.3) 14.7 (10.6)   40.9 (17.5) 63.5 (23.7)  
Median 8.8 11.3   37.4 58.9  
Range 2.6–27.2 2.9–39.6   17.4–74.2 33.7–100.6  
V8Gy    0.0001    0.001
Mean (SD) 17.3 (13.5) 25.4 (17.4)   74.0 (40–0) 113.9 (52.8)  
Median 13.2 19.5   62.8 102.7  
Range 3.7–157 4.6–184   27.2–157 58.2–184.0  
V5Gy    0.0001    0.001
Mean (SD) 45.7 (40.4) 73.0 (57.6)   291.2 (174.9) 427.8 (183.3)  
Median 31.4 53.9   259.2 368.6  
Range 8.18–153.4 11.3–194.0   77.3–701.8 206.4–707.8  
Right hippocanpus    0.004    0.0012
Mean dose (SD) 1.34 (0.8) 1.67 (1.1)   3.8 (1.7) 4.7 (2.1)  
Median dose 1.0 1.54   3.2 3.9  
Range 0.6–3.6 0.6–4.9   1.9–6.9 2.6–8.6  
Left hippocanpus    0.03    0.007
Mean dose (SD) 1.69 (0.85) 1.92 (1.2)   3.6 (1.3) 4.7 (1.8)  
Median dose 1.61 1.65   3.0 4.9  
Range 0.5–4.3 0.5–6.2   2.2–6.4 2.99–9.8  
  1. DCAT Dynamic Conformal Arc Therapy, VMAT Volumetric Modulated Arc Therapy, GTV Gross Tumor Volume, V12Gy, V10Gy, V8Gy, and V5 Gy volume of normal brain (brain—GTV) receiving 12 Gy, 10 Gy, 8 Gy, and 5 Gy