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Table 3 Brain dose and V12Gy, V10Gy, V8Gy, and V5 Gy among DCAT and VMAT plans with 1–10 or > 10 lesions

From: Single-isocenter multiple-target stereotactic radiosurgery for multiple brain metastases: dosimetric evaluation of two automated treatment planning systems

Parameter

DCAT

VMAT

p

DCAT

VMAT

p

1–10 lesions

1–10 lesions

> 10 lesions

> 10 lesions

Brain dose

  

0.003

  

0.001

Mean dose (SD)

1.7 (0.6)

1.88 (0.8)

 

2.64 (1.3)

3.01 (1.5)

 

Median dose (SD)

1.63

1.77

 

2.3

2.7

 

Range

0.65–3.0

0.55–3.48

 

0.65–5.62

0.55–5.85

 

V12Gy

  

0.0001

  

0.001

Mean (SD)

7.7 (5.0)

10.5 (6.8)

 

25.8 (10.6)

39.7 (13.7)

 

Median

6.2

8.2

 

22.7

38.7

 

Range

1.87–18.1

2.2–26.4

 

12.2–45.9

21.9–62.3

 

V10Gy

  

0.0005

  

0.001

Mean (SD)

10.9 (7.3)

14.7 (10.6)

 

40.9 (17.5)

63.5 (23.7)

 

Median

8.8

11.3

 

37.4

58.9

 

Range

2.6–27.2

2.9–39.6

 

17.4–74.2

33.7–100.6

 

V8Gy

  

0.0001

  

0.001

Mean (SD)

17.3 (13.5)

25.4 (17.4)

 

74.0 (40–0)

113.9 (52.8)

 

Median

13.2

19.5

 

62.8

102.7

 

Range

3.7–157

4.6–184

 

27.2–157

58.2–184.0

 

V5Gy

  

0.0001

  

0.001

Mean (SD)

45.7 (40.4)

73.0 (57.6)

 

291.2 (174.9)

427.8 (183.3)

 

Median

31.4

53.9

 

259.2

368.6

 

Range

8.18–153.4

11.3–194.0

 

77.3–701.8

206.4–707.8

 

Right hippocanpus

  

0.004

  

0.0012

Mean dose (SD)

1.34 (0.8)

1.67 (1.1)

 

3.8 (1.7)

4.7 (2.1)

 

Median dose

1.0

1.54

 

3.2

3.9

 

Range

0.6–3.6

0.6–4.9

 

1.9–6.9

2.6–8.6

 

Left hippocanpus

  

0.03

  

0.007

Mean dose (SD)

1.69 (0.85)

1.92 (1.2)

 

3.6 (1.3)

4.7 (1.8)

 

Median dose

1.61

1.65

 

3.0

4.9

 

Range

0.5–4.3

0.5–6.2

 

2.2–6.4

2.99–9.8

 
  1. DCAT Dynamic Conformal Arc Therapy, VMAT Volumetric Modulated Arc Therapy, GTV Gross Tumor Volume, V12Gy, V10Gy, V8Gy, and V5 Gy volume of normal brain (brain—GTV) receiving 12 Gy, 10 Gy, 8 Gy, and 5 Gy