Table 2 Results and significance level of gynaecological malignancies

Oliai et al., 2012 [17]

50% (one out of two patients) time to bleeding recurrence after HBOT was 17 months and a reduction from persistent to intermittent hematuria was reported

NR

50% (one out of two patients) time to bleeding recurrence after HBOT was 3 months. The patient had a recurrence from persistent to intermittent hematuria, was diagnosed subsequently with bladder cancer after HBOT and underwent 30 extra treatments

0.89 mean reduction LENT-SOMA score

Sidik et al., 2007 [18]

43.41% LENT-SOMA difference between treatment and control group soon after intervention

p-value LENT-SOMA soon < 0.001

13.95% LENT-SOMA difference between treatment and control group six months after HBOT

p-value LENT-SOMA 6 months = 0.008

15.14% Karnofsky difference between treatment and control group soon after intervention

p-value Karnofsky soon < 0.001

12.80% Karnofsky difference between treatment and control group six months after HBOT

p-value Karnofsky 6 months = 0.007

Parra et al., 2011 [20]

100% (four out of four patients) complete resolution of macroscopic bleeding after HBOT

NR

Rud et al., 2009 [21]

50% of the patients reported some or good effect

NR

50% of the patients experienced big changes such as major fractures and/or marked soft tissue oedema

Insignificant difference in use or frequency of pain descriptors after HBOT, the use of analgesics, BPI or depression scale scores and MADRS after HBOT

MR imaging showed signal abnormalities in 93.75% of the patients and a variety of changes was reported

Safra et al., 2008 [22]

100% resolution of macroscopic hematuria

100% resolution of scar complications

3.0 points mean improvement of CTC change in cystitis and proctitis

p-value CTC score = 0.001

2.8 points mean improvement of CTC change in recto-vaginal fistulas, vesico-vaginal fistulas and vaginal ulcers

4.0 points mean improvement of CTC change in wound healing complications

Williams et al., 1992 [24]

92.9% of the patients had a complete recovery or improvement of necrosis and fistulas

NR

Feldmeier et al., 1996 [25]

61.3% of the patients recovered from the injuries after HBOT

NR

6.5% of the patients did not recover from the injuries after HBOT

25.8% of the patients received inadequate number of treatments and were all deceased

6.5% of the patients were lost to follow-up

Al-Ali et al., 2010 [26]

100% (two out of two patients) reported no response in the treatment group to hemorrhagic cystitis

NR

100% (one out of one patient) had spontaneous bleeding stop in the control group

Fink et al., 2006 [34]

71.4% of the patients recovered from delayed radiation injuries or improved more than 50%

NR

14.3% of the patients (two patients) bleeding recurred after 10 and 11 months

Highest success rate in patients with necrotic ulcers with 50% of the patients having complete healing and 50% of the patients achieving a 50% improvement