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Table 7 Acute and chronic gastrointestinal toxicity by dosimetric parameters

From: The prognostic significance of pretreatment squamous cell carcinoma antigen levels in cervical cancer patients treated by concurrent chemoradiation therapy and a comparison of dosimetric outcomes and clinical toxicities between tomotherapy and volumetric modulated arc therapy

 

CTCAE Grade 2 + acute diarrhea

CTCAE Grade 2 + chronic colitis

Odds ratio

95% CI

P

Odds ratio

95% CI

P

Colon

V35

0.88

0.73–1.06

0.182

1.10

0.86–1.41

0.451

V25

1.14

0.93–1.40

0.202

0.82

0.60–1.13

0.224

V15

0.93

0.83–1.04

0.186

1.05

0.93–1.18

0.448

Peritoneum

V50.4

0.80

0.57–1.12

0.198

1.09

0.76–1.56

0.629

V40

1.62

0.97–2.71

0.068

0.93

0.63–1.36

0.698

V30

0.80

0.54–1.18

0.250

1.25

0.83–1.87

0.287

V25

0.99

0.83–1.17

0.892

1.02

0.89–1.16

0.792

Rectum

V50.4

1.01

0.92–1.11

0.863

0.97

0.87–1.08

0.576

V40

0.92

0.83–1.02

0.116

0.84

0.67–1.06

0.147

V30

1.15

1.10–1.30

0.030*

1.14

0.99–1.33

0.073

  1. CTCAE common terminology criteria for adverse events, CI confidence interval, V50.4, V40, V35, V30, V25, V15 = volume receiving ≥ 50.4, ≥ 40, ≥ 35, ≥ 30, ≥ 25, ≥ 15 Gy, respectively
  2. *Statistically significant