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Table 1. Case characteristics, timeline and outcome

From: Ocular complications with the use of radium-223: a case series

Patient

Characteristics

Timing of ocular symptoms

Presentation

Formal diagnosis

Treatment

Resolution

1

74 M, G9 (4 + 5), ATM and BRAF mutations, cardiac comorbidities, bilateral cataracts and bilateral ocular hypertension, prior Ra-223 treatment

2 weeks after first cycle of Ra-223

Bilateral blurry vision

Anterior uveitis, hyphema of the left eye

Prednisolone acetate 1% 4× daily, atropine 1% daily and brimonidine 0.2% daily

Bilateral anterior uveitis and left eye hyphema resolved within 2 months

2

78 M, G9 (4 + 5), history of right eye strabismic amblyopia, bilateral macular drusen, bilateral narrow angles; no genetic pathologic mutations

1 week after first cycle of Ra-223

Monocular blurry vision

Posterior capsular opacification (PCO) with stable drusen

Laser capsulotomy (underlying PCO unlikely related to Ra-223)

Partial improvement in blurry vision

3

74 M, G7 (4 + 3), history of mild cognitive impairment; concurrent use of enzalutamide

48 hours after first cycle of Ra-223

Bilateral blurry vision

Normal eye exam

None

Blurry vision stabilized after 2 weeks