From: Ocular complications with the use of radium-223: a case series
Patient | Characteristics | Timing of ocular symptoms | Presentation | Formal diagnosis | Treatment | Resolution |
---|---|---|---|---|---|---|
1 | 74 M, G9 (4 + 5), ATM and BRAF mutations, cardiac comorbidities, bilateral cataracts and bilateral ocular hypertension, prior Ra-223 treatment | 2 weeks after first cycle of Ra-223 | Bilateral blurry vision | Anterior uveitis, hyphema of the left eye | Prednisolone acetate 1% 4× daily, atropine 1% daily and brimonidine 0.2% daily | Bilateral anterior uveitis and left eye hyphema resolved within 2 months |
2 | 78 M, G9 (4 + 5), history of right eye strabismic amblyopia, bilateral macular drusen, bilateral narrow angles; no genetic pathologic mutations | 1 week after first cycle of Ra-223 | Monocular blurry vision | Posterior capsular opacification (PCO) with stable drusen | Laser capsulotomy (underlying PCO unlikely related to Ra-223) | Partial improvement in blurry vision |
3 | 74 M, G7 (4 + 3), history of mild cognitive impairment; concurrent use of enzalutamide | 48 hours after first cycle of Ra-223 | Bilateral blurry vision | Normal eye exam | None | Blurry vision stabilized after 2 weeks |