Early-onset adverse events after stereotactic radiosurgery for jugular foramen schwannoma: a mid-term follow-up single-center review of 46 cases

Table 2 Basic demographic characteristics and radiosurgical treatment parameters according to the occurrence of pre-existing symptoms

Characteristics	Pre-existing symptoms group	Non pre-existing symptoms group	P value
Patients	27 (58.7)	19 (41.3)
Median age at GKRS (year)	48 (13–83)	55 (11–76)	0.040^a
Sex			0.767^b
Male	10 (37.0)	8 (42.1)
Female	17 (63.0)	11 (57.9)
Laterality			0.767^b
Left	17 (63.0)	11 (57.9)
Right	10 (37.0)	8 (42.1)
Tumour component			0.440^b
Solid	21 (77.8)	17 (89.5)
Cystic	6 (22.2)	2 (10.5)
Brainstem contact	17 (63.0)	12 (63.2)	1.000^b
Prior microsurgery	13 (48.1)	2 (10.6)	0.010^b
Tumor type^c
A: Primary intracranial	5 (18.6)	11 (57.9)	0.006^a
B: Jugular foramen with intracranial extension	2 (7.4)	1 (5.3)	1.000^a
C: Primary extracranial with foraminal extension	6 (22.1)	3 (15.8)	0.774^a
D: Intra-/extracranial extension (dumb-bell shaped)	14 (51.9)	4 (21.1)	0.034^a
Median tumour volume (cm³)	4.2 (0.5–13.7)	1.7 (0.2–10.8)	0.010^a
Median follow-up period, month	48 (9–135)	61 (24–136)	0.359^a
Median marginal dose (Gy)	13.0 (12.0–14.0)	13.0 (12.0–14.0)	0.861^a
Median maximal dose (Gy)	26.0 (24.0–28.7)	26.1 (24.2–28.5)	0.910^a

Values are expressed as numbers (%) or medians (range)
GKRS gamma knife radiosurgery
^aStatistical testing was performed using the Mann–Whitney U test and Student’s t test
^bStatistical testing was performed using the Chi-square test or Fisher’s exact test
^cTumor types in this study according to Kaye’s modified classification

ISSN: 1748-717X