Table 2 Characteristics of patients with radiation-induced gliomas
Case no. | Sex | Age (years) | Secondary disease | Karnofsky performance status | Location | Leukoencephalopathy | Comorbidity | Initial treatment | Recurrent pattern | Treatment at first recurrence | PFS (months) | OS (months) | Status | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Operation | Chemotherapy | Radiation therapy | Operation | Chemotherapy | Radiation therapy | ||||||||||||
1 | M | 45 | GBM, NOS | 80 | Rt. insula | Grade I | Visual dysfunction | Partial removal | ACNU | No | Local | BSC | Â | Â | 28.1 | 34.5 | Dead |
2 | M | 45 | AA, NOS | 70 | Rt. temporal | No | No | Partial removal | TMZ | No | Local | BSC | Â | Â | 3.0 | 8.4 | Dead |
3 | M | 10 | GBM, IDH1/2-Wildtype | 80 | Lt. frontal Lt. parietal | No | Short stature | Biopsy | ACNU | Local RT 40Â Gy/20fr | Local | No | Carboplatin, Etoposide | No | 3.8 | 11.0 | Dead |
4 | M | 33 | GBM, IDH1/2-Wildtype | 60 | Rt. Cerebellum Pons (dissemination) | Grade II | Hypopituitarism | Biopsy | Carboplatin, Etoposide | No | Dissemination | BSC | Â | Â | 2.5 | 4.6 | Dead |
5 | F | 34 | GBM, IDH1/2-Wildtype | 80 | Lt. temporal | No | Hypopituitarism Visual dysfunction | Total removal | TMZ | No | Local | Subtotal removal | TMZ | Local RT 45Â Gy/25f | 11.3 | 27.5 | Dead |
6 | F | 39 | AA, IDH1/2-Wildtype | 60 | Rt. Parietal Rt. occipital | No | Mild cognitive impairment | Rt. parietal: partial removal Rt. occipital: partial removal | TMZ | No | Local | Rt. Parietal: Total removal Rt. Occipital: Total removal | TMZ | Local RT 60Â Gy/30fr | 8.8 | 27.3 | Dead |
7 | F | 23 | GBM, IDH1/2-Wildtype | 90 | Rt. frontal | No | Mild cognitive impairment | Subtotal removal | TMZ | No | Local | No | TMZ | SRT 40Â Gy/10fr | 7.4 | 29.1 | Dead |
8 | M | 17 | GBM, NOS | 90 | Rt. parietal | No | No | Total removal | TMZ | Local RT 66Â Gy/33fr | Local | No | No | GKS | 17.0 | 30.8 | Dead |
9 | F | 32 | GBM, IDH1/2-Wildtype | 80 | Lt. frontal-parietal | Grade II | No | Biopsy | TMZ | Local RT 60Â Gy/30fr | Distant | No | TMZ | SRT 42Â Gy/7fr | 23.0 | 35.1 | Dead |
10 | F | 49 | GBM, IDH1/2-Wildtype | 90 | Rt. frontal | No | No | Total removal | TMZ, Bev | Local RT 50Â Gy/25fr | Distant | Biopsy | Bev | SRT 42Â Gy/7fr | 15.9 | 28.3 | Dead |
11 | M | 28 | GBM, IDH1/2-Wildtype | 60 | Lt. cerebellum | No | Mild cognitive impairment | Biopsy | TMZ, Bev | Local RT 40Â Gy/15fr | No recurrence | No recurrence | Â | Â | 9.8 | 9.8 | Alive |