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Table 3 Grade 2–3 dermatitis according to risks factors and fractionation

From: Favorable safety profile of moderate hypofractionated over normofractionated radiotherapy in breast cancer patients: a multicentric prospective real-life data farming analysis

Dermatitis grade 2–3

Total (n = 622)

NFRT (n = 317)

p value univariate NFRT

HFRT (n = 305)

p value univariate HFRT

p value multivariate on all patientsa

Odds ratio multivariate on all patientsa [CI 95%]

Body mass index

 < 25 kg/m2

25/280 (8.9)

19/130 (14.6)

< 0.001

6/150 (4.0)

0.17

0.007

2.30 [1.28–4.26]

 ≥ 25 kg/m2

85/339 (25.1)

73/185 (39.5)

 

12/154 (7.8)

   

 NA

3 (0.5)

1/2

 

0/1

   

Bra cup size

 A–C

47/351 (13.4)

39/172 (22.7)

< 0.001

8/179 (4.5)

0.17

0.03

1.88 [1.07–3.28]

 D–J

45/154 (29.2)

39/89 (43.8)

 

6/65 (9.2)

   

 NA

117 (18.8)

15/56

 

4/61

   

Chemotherapy

 No

35/295 (11.9)

25/74 (33.8)

0.34

10/221 (4.5)

0.11

0.59

0.84 [0.45–1.57]

 Yes

76/327 (23.2)

68/243 (28.0)

 

8/84 (9.5)

   

Type of surgery

 Lumpectomy

62/412 (15.0)

45/142 (31.7)

0.02

17/270 (6.3)

0.98

0.04

0.52 [0.27–0.97]

 Mastectomy

28/177 (15.8)

28/145 (19.3)

 

0/32 (0.0)

   

 Other

33 (5.3)

20/30

 

1/3

   
  1. Values are number (percentage) unless otherwise specified
  2. HFRT : hypofractionated radiotherapy, NFRT : normofractionated radiotherapy, CI : confidence interval, NA : not available
  3. aWith addition of the covariate type of radiotherapy (HFRT or NFRT)