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Table 2 The statistical data [mean ± standard deviation] for all three PTVs and OARs are shown for selected dose-volume Points and NTCP values for the patient data from 2016 to 2020

From: Retrospective evaluation of a robust hybrid planning technique established for irradiation of breast cancer patients with included mammary internal lymph nodes

Parameters

PTVBreast

PTVSupra

PTVMI

Original fractionation

Original fractionation

Original fractionation

# matched volumes

217

135

170

Volume (cm3)

664.3 ± 331

166.7 ± 121.8

22.3 ± 14.1

Length cr–cd (cm)

16.3 ± 1.8

5.3 ± 2.4

9.7 ± 1.9

Dmean (%)

100.5 ± 1

100.3 ± 0.9

100 ± 1.2

D50% (%)

101 ± 1

100.6 ± 0.9

100.3 ± 1.1

Dmax (%)

111.1 ± 2.2

108.9 ± 2

108 ± 2.1

D98% (%)

91.2 ± 6.4

93.6 ± 2.1

93.5 ± 3.2

D95% (%)

94.2 ± 3.7

95.4 ± 1.7

94.9 ± 2.7

D2% (%)

105.9 ± 1.5

105 ± 1.5

104.9 ± 1.7

Dmin (%)

57.9 ± 21.9

80.1 ± 7

85.3 ± 6.1

V90% (%)

98.6 ± 2

99.5 ± 0.8

99 ± 2.6

V95% (%)

94.2 ± 3.6

95.2 ± 3.6

93.2 ± 8.2

 

Lung total

Lung contralateral

Lung ipsilateral

Heart

Original fractionation

25 × 2Gy = 50 Gy

Original fractionation

25 × 2Gy = 50 Gy

Original fractionation

25 × 2Gy = 50 Gy

Original fractionation

25 × 2Gy = 50 Gy

# matched volumes

213

216

216

212

Volume (cm3)

4468.5 ± 789.8

 

2213.9 ± 470.1

 

2237.2 ± 420.7

 

529.7 ± 103.5

 

Dmean (Gy)

6.5 ± 0.9

6.6 ± 0.9

2.2 ± 0.6

2.2 ± 0.6

10.9 ± 1.5

11 ± 1.4

2.1 ± 1.1

2.2 ± 1.1

V5Gy (%)

  

10.2 ± 5.9

10.7 ± 5.8

  

10.9 ± 9.7

11.3 ± 10.1

V20Gy (%)

9.5 ± 1.9

9.6 ± 1.8

  

18.9 ± 3.7

19.2 ± 3.5

  

V25Gy (%)

      

0.1 ± 0.5

0.1 ± 0.5

NTCP (%)

2.8 ± 0.5

 

2.1 ± 0.6

0.02 ± 0.17

Model:

Semenenko 2008: symptomatic pneumonitis total lung

  

Semenenko 2008: symptomatic pneumonitis ipsilateral lung

Schneider 2017: relative seriality model: long-term cardiac mortality

 

Spinal cord

Esophagus

Breast contralateral

original fractionation

25 × 2Gy = 50 Gy

original fractionation

25 × 2Gy = 50 Gy

original fractionation

25 × 2Gy = 50 Gy

# matched volumes

214

139

84

Volume (cm3)

35.9 ± 15.3

 

14.5 ± 6.4

 

789.1 ± 409.7

 

Length cr–cd (cm)

18.9 ± 7.4

 

11.4 ± 4

   

Dmean (Gy)

5.4 ± 2.6

5.5 ± 2.6

10.5 ± 3.4

10.7 ± 3.4

1.7 ± 0.6

1.7 ± 0.6

Dmax (Gy)

17.1 ± 4.4

17.4 ± 4.4

    

D2% (Gy)

14.7 ± 3.8

15 ± 3.8

20.9 ± 6.1

21.2 ± 6.1

  

V5Gy (%)

    

2.4 ± 3.9

2.5 ± 4

NTCP (%)

  

1.9 ± 1.2

   

Model

  

Belderbos 2005: acute esophagitis grade 2+

  
  1. The whole evaluation for the PTVs is done with the relative DVHs and for the OARs with the absolute DVHs. The evaluation for the OARs is done for the original fractionation schemes of the plans and additionally with renormalized DVHs for a uniform fractionation of \(25\times 2\) Gy = 50 Gy