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Table 2 The statistical data [mean ± standard deviation] for all three PTVs and OARs are shown for selected dose-volume Points and NTCP values for the patient data from 2016 to 2020

From: Retrospective evaluation of a robust hybrid planning technique established for irradiation of breast cancer patients with included mammary internal lymph nodes

Parameters PTVBreast PTVSupra PTVMI
Original fractionation Original fractionation Original fractionation
# matched volumes 217 135 170
Volume (cm3) 664.3 ± 331 166.7 ± 121.8 22.3 ± 14.1
Length cr–cd (cm) 16.3 ± 1.8 5.3 ± 2.4 9.7 ± 1.9
Dmean (%) 100.5 ± 1 100.3 ± 0.9 100 ± 1.2
D50% (%) 101 ± 1 100.6 ± 0.9 100.3 ± 1.1
Dmax (%) 111.1 ± 2.2 108.9 ± 2 108 ± 2.1
D98% (%) 91.2 ± 6.4 93.6 ± 2.1 93.5 ± 3.2
D95% (%) 94.2 ± 3.7 95.4 ± 1.7 94.9 ± 2.7
D2% (%) 105.9 ± 1.5 105 ± 1.5 104.9 ± 1.7
Dmin (%) 57.9 ± 21.9 80.1 ± 7 85.3 ± 6.1
V90% (%) 98.6 ± 2 99.5 ± 0.8 99 ± 2.6
V95% (%) 94.2 ± 3.6 95.2 ± 3.6 93.2 ± 8.2
  Lung total Lung contralateral Lung ipsilateral Heart
Original fractionation 25 × 2Gy = 50 Gy Original fractionation 25 × 2Gy = 50 Gy Original fractionation 25 × 2Gy = 50 Gy Original fractionation 25 × 2Gy = 50 Gy
# matched volumes 213 216 216 212
Volume (cm3) 4468.5 ± 789.8   2213.9 ± 470.1   2237.2 ± 420.7   529.7 ± 103.5  
Dmean (Gy) 6.5 ± 0.9 6.6 ± 0.9 2.2 ± 0.6 2.2 ± 0.6 10.9 ± 1.5 11 ± 1.4 2.1 ± 1.1 2.2 ± 1.1
V5Gy (%)    10.2 ± 5.9 10.7 ± 5.8    10.9 ± 9.7 11.3 ± 10.1
V20Gy (%) 9.5 ± 1.9 9.6 ± 1.8    18.9 ± 3.7 19.2 ± 3.5   
V25Gy (%)        0.1 ± 0.5 0.1 ± 0.5
NTCP (%) 2.8 ± 0.5   2.1 ± 0.6 0.02 ± 0.17
Model: Semenenko 2008: symptomatic pneumonitis total lung    Semenenko 2008: symptomatic pneumonitis ipsilateral lung Schneider 2017: relative seriality model: long-term cardiac mortality
  Spinal cord Esophagus Breast contralateral
original fractionation 25 × 2Gy = 50 Gy original fractionation 25 × 2Gy = 50 Gy original fractionation 25 × 2Gy = 50 Gy
# matched volumes 214 139 84
Volume (cm3) 35.9 ± 15.3   14.5 ± 6.4   789.1 ± 409.7  
Length cr–cd (cm) 18.9 ± 7.4   11.4 ± 4    
Dmean (Gy) 5.4 ± 2.6 5.5 ± 2.6 10.5 ± 3.4 10.7 ± 3.4 1.7 ± 0.6 1.7 ± 0.6
Dmax (Gy) 17.1 ± 4.4 17.4 ± 4.4     
D2% (Gy) 14.7 ± 3.8 15 ± 3.8 20.9 ± 6.1 21.2 ± 6.1   
V5Gy (%)      2.4 ± 3.9 2.5 ± 4
NTCP (%)    1.9 ± 1.2    
Model    Belderbos 2005: acute esophagitis grade 2+   
  1. The whole evaluation for the PTVs is done with the relative DVHs and for the OARs with the absolute DVHs. The evaluation for the OARs is done for the original fractionation schemes of the plans and additionally with renormalized DVHs for a uniform fractionation of \(25\times 2\) Gy = 50 Gy