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Fig. 6 | Radiation Oncology

Fig. 6

From: Ganetespib selectively sensitizes cancer cells for proximal and distal spread-out Bragg peak proton irradiation

Fig. 6

Dose-modifying factor of ganetespib in FaDu cells in response to photon, proximal SOBP, and distal SOBP irradiation. FaDu cells irradiated with photon reference IR do not exhibit a radiosensitizing effect upon ganetespib treatment (A). In contrast, the linear-quadratic model highlights differences in FaDu cells upon irradiation with B proximal SOBP and C distal SOBP protons in dependence of sham or ganetespib treatment. Consequently, the DMF of ganetespib at D 50%, E 25%, and F 10% cell survival is significantly higher in FaDu cells irradiated with either of the two proton modalities compared to reference photon IR. Proximal and distal SOBP corresponds to a LET of 2.1 respectively 4.5 keV/μm and statistical testing was performed by unpaired, two-tailed t test with Welch’s Correction with error bars indicating the standard deviation

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