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Fig. 1 | Radiation Oncology

Fig. 1

From: Ganetespib selectively sensitizes cancer cells for proximal and distal spread-out Bragg peak proton irradiation

Fig. 1

Proliferation assay of A549 and FaDu cells, treated with varying concentrations of ganetespib and irradiated with sham, 3 Gy, or 6 Gy of reference photon irradiation. Proliferative capacity was determined by alamarBlue assay of A549 (A–C) and FaDu (D–F) cells. Cells were irradiated with 0 Gy (A, D), 3 Gy (B, E), or 6 Gy (C, F) of reference photon irradiation. 30 nM and 300 nM ganetespib are sufficient to inhibit proliferation of A549 and FaDu cells irrespective of the administration of sham or actual irradiation. Importantly, there is no significant difference between 0 and 3 nM ganetespib, irrespective of the photon radiation dose administered. Statistical testing was performed by unpaired, two-tailed t test with Welch’s Correction with error bars indicating the standard deviation

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