Table 2 Prognostic factors for radiotherapy response
Variables | No. (%) | Univariate | Mulitivariate | ||
|---|---|---|---|---|---|
OR (95% CI) | p value | OR (95% CI) | p value | ||
Sex | 0.91 (0.42–2.0) | 0.813 | |||
Male | 120 (69) | ||||
Female | 54 (31) | ||||
Age | 2.68 (1.25–5.78) | 0.012 | |||
≤ 68 | 81 (46.6) | ||||
> 68 | 93 (53.4) | ||||
ECOG | 0.84 (0.31–2.27) | 0.725 | |||
ECOG 0–1 | 140 (80.5) | ||||
ECOG 2–3 | 34 (19.5) | ||||
Primary location | 0.25 (0.11–0.58) | 0.001 | |||
Renal pelvis | 87 (53) | ||||
Ureter | 77 (47) | ||||
Multifocality | 0.62 (0.22–1.76) | 0.368 | |||
Yes | 23 (13.2) | ||||
No | 151 (86.8) | ||||
Tumor size | 0.8 (0.34–1.91) | 0.615 | |||
< 4 cm | 59 (46.8) | ||||
≥ 4 cm | 67 (53.2) | ||||
Radical nephroureterectomy | 0.69 (0.28–1.67) | 0.406 | |||
Yes | 135 (77.6) | ||||
No | 39 (22.4) | ||||
Resection margin | 1.14 (0.34–3.87) | 0.835 | |||
Negative | 95 (68.3) | ||||
Close or positive | 44 (31.7) | ||||
Lymphovascular invasion | 0.35 (0.15–0.82) | 0.016 | |||
Negative | 83 (62.4) | ||||
Positive | 50 (37.6) | ||||
Perineural invasion | 0.55 (0.20–1.52) | 0.245 | |||
Negative | 112 (84.2) | ||||
Positive | 21 (15.8) | ||||
Histologic grade | 0.86 (0.16–4.62) | 0.856 | |||
Low | 8 (5.3) | ||||
High | 144 (94.7) | ||||
PD-L1 | 0 (0–0) | 0.999 | |||
Negative | 36 (83.7) | ||||
Positive | 7 (16.3) | ||||
Concurrent chemotherapy | 2.22 (1.02–4.85) | 0.045 | 2.91 (1.11–7.65) | 0.03 | |
Yes | 101 (58) | ||||
No | 73 (42) | ||||
Interval between diagnosis to first recurrence | 0.56 (0.27–1.17) | 0.124 | |||
> 8 m | 81 (48.8) | ||||
≤ 8 m | 85 (51.2) | ||||
RT methods | 0.53 (0.25–1.15) | 0.107 | |||
2D/3D | 61 (35.1) | ||||
IMRT | 113 (64.9) | ||||
Radiation dose | 0.38 (0.18–0.81) | 0.011 | 2.67 (1.08–6.64) | 0.034 | |
≥ 45 Gy | 81 (46.6) | ||||
< 45 Gy | 93 (53.4) | ||||