Table 1 Patient characteristics
Variables | No. (%) |
|---|---|
Age | |
Median | 68 (37–90) |
Sex | |
Male | 120 (69) |
Female | 54 (31) |
ECOG | |
0 | 8 (4.6) |
1 | 132 (75.9) |
2 | 26 (14.9) |
3 | 8 (4.6) |
Primary site | |
Renal pelvis | 87 (50) |
Ureter | 77 (44.3) |
Pelvis and ureter | 10 (5.7) |
Multifocality | |
No | 151 (86.8) |
Yes | 23 (13.2) |
Tumor size | |
Median (cm) | 4.1 (0.3–18.0) |
Grade | |
Low | 8 (4.6) |
High | 144 (82.8) |
NA | 22 (12.6) |
Lymphovascular invasion | |
Negative | 83 (47.7) |
Positive | 50 (28.7) |
NA | 41 (23.6) |
Perineural invasion | |
Negative | 112 (64.3) |
Positive | 21 (12.1) |
NA | 41 (23.6) |
PD-L1 | |
Negative | 36 (20.7) |
Positive | 7 (4) |
NA | 131 (75.3) |
Initial stage | |
0a | 2 (1.1) |
0is | 2 (1.1) |
I | 18 (10.3) |
II | 19 (11) |
III | 52 (29.9) |
IV | 77 (44.3) |
NA | 4 (2.3) |
Present disease status | |
Initially diagnosed | 8 (4.6) |
Local recurrence only | 56 (32.2) |
Distant metastasis only | 59 (33.9) |
Local recurrence and distant metastasis | 51 (29.3) |
Interval between diagnosis and first recurrence | |
Median (month) | 8 (1–106) |
Surgery | |
Radical nephroureterectomy | 135 (77.6) |
Ureter segmental resection/Nephrectomy | 8 (4.6) |
LN dissection only | 1 (0.6) |
Biopsy only | 15 (8.6) |
No | 15 (8.6) |
Resection margin (n = 144) | |
Negative | 94 (65.3) |
Close | 25 (17.3) |
Positive | 18 (12.5) |
NA | 7 (4.9) |
Chemotherapy at radiotherapy | |
Yes | 101 (58) |
No | 73 (42) |
Immunotherapy at radiotherapy | |
Yes | 19 (10.9) |
No | 155 (89.1) |
Aim of radiotherapy | |
Salvage | 73 (42) |
Palliative | 101 (58) |
Radiotherapy method | |
2D/3D | 61 (35.1) |
IMRT | 113 (64.9) |
Total dose | |
Median (Gy) | 45 (range, 15–65) |
Fractional dose | |
Median (Gy) | 2.65 (range, 1.65–20) |