Table 2 Comparison of OARs dose in the Pre-boost plan and Mid-boost plan
From: A prospective comparison of adaptive and fixed boost plans in radiotherapy for glioblastoma
Fixed boost plan | Adaptive boost plan | P value | |
|---|---|---|---|
Median (range) | Median (range) | ||
D2% to OARs (Gy) | |||
All patients | |||
Ipsilateral optic nerve | 7.4 (0.3–17.1) | 7.3 (0.3–19.9) | 0.62 |
Contralateral optic nerve | 5.1 (0.3–12.9) | 4.6 (0.3–20.6) | 0.98 |
Optic chiasm | 9.2 (0.6–18.9) | 9.9 (0.6–20.) | 0.22 |
Brain stem | 16.2 (0.9–20.4) | 18.2 (0.8–20.4) | 0.85 |
Patients with GTR | |||
Ipsilateral optic nerve | 7.4 (0.3–17.1) | 7.6 (0.3–14.6) | 0.93 |
Contralateral optic nerve | 5.1(0.3–12.9) | 4.6 (0.3–13.5) | 0.29 |
Optic chiasm | 8.9 (0.8–17.1) | 9.9 (0.6–15.2) | 0.20 |
Brain stem | 15.7 (1.7–20.4) | 18.5 (0.9–20.4) | 0.31 |
Patients with STR or biopsy | |||
Ipsilateral optic nerve | 7.9 (0.5–15.7) | 6.8 (0.5–19.9) | 0.59 |
Contralateral optic nerve | 5.2 (0.4–12.4) | 4.7 (0.4–20.1) | 0.30 |
Optic chiasm | 9.9 (0.6–18.9) | 9.9 (0.6–20.2) | 0.59 |
Brain stem | 16.9 (0.9–20.) | 18.1 (0.8–20.1) | 0.40 |
Vn(%) of normal brain (ml) | |||
All patients | |||
V10 | 35 (3–64.3) | 32.5 (9.3–70.7) | 0.57 |
V15 | 14.2 (22.0–45.9) | 14.2 (3.5–46.1) | 0.19 |
V20 | 2.8 (0–13.2) | 2.2 (0–14.8) | 0.23 |
Patients with GTR | |||
V10 | 28.9 (11.3–51.7) | 26.1 (9.3–56.8) | 0.01 |
V15 | 12.2 (2.2–23.5) | 9 (3.5–30.3) | 0.01 |
V20 | 2.0 (0–9.4) | 0.8 (0–13.7) | 0.01 |
Patients with PR or biopsy | |||
V10 | 39.2 (3–64.3) | 40.2 (24.1–70.7) | 0.17 |
V15 | 18.7 (7.4–45.9) | 19 (8–46.1) | 0.72 |
V20 | 3.4 (0.4–13.2) | 2.9 (0.3–14.8) | 0.59 |