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Table 2 Univariate and multivariate analyses of prognostic factors for overall survival

From: Factors associated with long-term survival in gemcitabine-concurrent proton radiotherapy for non-metastatic locally advanced pancreatic cancer: a single-center retrospective study

  

Univariate

Multivariate

Variables

n (%)

HR (95% CI)

P value

HR (95% CI)

P value

Age ≧ 65 years

57 (46)

1.47 (0.97–2.22)

0.069

1.52 (0.99–2.33)

0.053

Gender, Male

65 (53)

0.82 (0.55–1.24)

0.351

  

ECOG-PS, 0

94 (76)

0.93 (0.59–1.47)

0.744

  

Tumor location, Body-tail

64 (52)

0.50 (0.33–0.76)

0.001

0.12 (0.02–0.91)

0.040

CEA ≧ 5 ng/mL

34 (28)

1.27 (0.82–1.97)

0.291

  

CA19-9 ≧ 37 U/mL

104 (85)

0.98 (0.55–1.74)

0.940

  

Pathological diagnosis, Yes

75 (61)

0.89 (0.59–1.35)

0.589

  

Lymph node metastasis, Negative

82 (67)

1.04 (0.68–1.60)

0.846

  

Bile duct invasion, Negative

60 (49)

0.61 (0.40–0.92)

0.018

7.22 (0.76–68.4)

0.085

Duodenal invasion, Negative

59 (48)

0.57 (0.38–0.87)

0.009

0.55 (0.19–1.63)

0.283

Anterior peripancreatic invasion, Negative

19 (15)

0.50 (0.27–0.92)

0.027

0.46 (0.25–0.86)

0.015

GTV V60GyE ≧ 60%

59 (48)

0.77 (0.51–1.16)

0.208

  
  1. HR hazard ratio; CI confidence interval; ECOG-PS Eastern Cooperative Oncology Group-Performance Status; CEA carcinoembryonic antigen; CA19-9 carbohydrate antigen 19–9; GTV gross tumor volume; GyE Gy equivalents; V60GyE the volume ratio irradiated over 60 GyE
  2. Significant P values (< 0.05) are in bold