Table 2 Univariable and multivariable analyses for grade ≥ 2 and grade ≥ 3 late rectal bleeding

Age (years)

  < 74

[Reference]

[Reference]

  ≥ 74

1.17 (0.5–2.33)

0.664

1.30 (0.53–3.17)

0.564

Risk category

 Very low–low

[Reference]

[Reference]

 Intermediate

0.81 (0.14–4.67)

0.817

0.30 (0.04–2.36)

0.255

 High–very high

1.66 (0.36–7.67)

0.517

0.85 (0.18–4.03)

0.833

Gleason score

 2–6

[Reference]

[Reference]

 7

1.40 (0.44–4.50)

0.572

0.82 (0.21–3.31)

0.786

 8–10

1.74 (0.54–5.58)

0.351

1.34 (0.35–5.14)

0.668

Initial PSA concentration (μg/L)

  < 10

[Reference]

[Reference]

 10–20

1.52 (0.64–3.64)

0.345

1.43 (0.49–4.15)

0.512

  ≥ 20

1.96 (0.83–4.59)

0.124

1.31 (0.44–3.94)

0.437

T stage

 T1–2

[Reference]

[Reference]

[Reference]

  ≥ T3

2.38 (1.04–5.45)

0.041

3.32 (1.28–8.65)

0.014

1.94 (0.69–5.48)

0.209

Diabetes

 No

[Reference]

[Reference]

 Yes

1.22 (0.53–2.77)

0.643

0.59 (0.17–2.09)

0.416

Hypertension

 No

[Reference]

[Reference]

[Reference]

 Yes

2.22 (1.08–4.58)

0.031

2.98 (1.32–6.69)

0.008

1.19 (0.49–2.87)

0.701

Cirrhosis

 No

[Reference]

[Reference]

[Reference]

[Reference]

 Yes

17.27 (3.34–89.26)

0.001

22.37 (3.65–36.99)

0.001

11.39 (2.63–49.40)

0.001

14.37 (3.09–66.87)

0.001

Whole-pelvic radiotherapy

 No

[Reference]

[Reference]

 Yes

1.56 (0.76–3.19)

0.226

1.35 (0.54–3.39)

0.517

Androgen-deprivation therapy

 Yes

[Reference]

[Reference]

 No

1.40 (0.65–3.05)

0.393

1.29 (0.48–3.49)

0.612

Radiation dose

 67.2 Gy

[Reference]

[Reference]

 70 Gy

1.6 (0.86–4.04)

0.117

1.28 (0.50–3.27)

0.611

IMRT technique

 Static

[Reference]

[Reference]

 Arc

1.02 (0.49–2.16)

0.953

0.97 (0.38–2.49)

0.945

Anticoagulation use

 No

[Reference]

[Reference]

[Reference]

 Yes

1.22 (0.60–2.49)

0.582

2.49 (1.02–6.05)

0.044

2.93 (1.14–7.55)

0.026

gEUD (Gy)

  < 58.3

[Reference]

[Reference]

[Reference]

 ≥ 58.3

3.01 (1.42–6.39)

0.004

2.42 (1.09–5.40)

0.031

1.49 (0.61–3.63)

0.384