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Table 2 Hazard ratios from frailty survival models using center as a random variable

From: PET/CT-based adaptive radiotherapy of locally advanced non-small cell lung cancer in multicenter yDEGRO ARO 2017-01 cohort study

 

Crudea

Adj.b

Effect of re-planning

 No Re.-pl

Ref

Ref

 Re.-pl

1.15 (0.84–1.57)

1.21 (0.89–1.64)

Effect of PET

 No PET

Ref

Ref

 PET

0.85 (0.58–1.24)

0.91 (0.62–1.34)

 PET coreg

0.76 (0.53–1.09)

0.8 (0.56–1.16)

Effect of PET usage in study centers

 PET coreg. versus No

0.83 (0.55–1.24)

0.72 (0.48–1.08)

 PET coreg. versus PET

0.96 (0.63–1.46)

0.8 (0.54–1.19)

 PET coreg. versus div

0.59 (0.37–0.94)

0.62 (0.41–0.94)

  1. Adjusted for GTV1, age, sex, sim. Chemotherapy, lung comorbidities, RT dose, grade
  2. a“center” as random variable, Re.-pl. re-planning, coreg. coregistration, div. diverse planning strategies
  3. bAdj. for GTV1, age, sex, sim. Chemotherapy, lung comorbidities, RT dose, grade