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Table 4 Multivariate analysis for overall survival in patients with limited-stage who had no brain metastases at baseline

From: Survival impact of prophylactic cranial irradiation in small-cell lung cancer in the modern era of magnetic resonance imaging staging

Variables

Multivariate analysis

Hazard ratio

95% CI

P

Age (years)a

 ≤ 68

Ref

  

 > 68

1.20

0.70‒2.05

0.520

Body mass index (kg/m2)a

 ≥ 23.6

Ref

  

 < 23.6

1.41

0.82‒2.41

0.210

No. of symptoms at diagnosis

0

Ref

  

 ≥ 1

2.48

1.19‒5.16

0.015

Clinical T stage

T1‒2

Ref

  

T3‒4

0.78

0.43‒1.42

0.416

Clinical N stage

N0‒1

Ref

  

N2‒3

3.01

1.25‒7.26

0.014

Definitive treatment

Chemoradiotherapyb

Ref

  

Othersc

1.14

0.41‒3.16

0.796

Chemotherapy

3.07

1.70‒5.56

 < 0.001

PCI

Yes

Ref

  

No

2.46

1.30‒4.63

0.005

  1. aThe median value was used as the cutoff point
  2. bCases with concurrent or sequential chemoradiotherapy were included
  3. cPatients who received radiotherapy alone or surgery (± adjuvant therapy) were included
  4. CI, confidence interval; Ref, reference; PCI, prophylactic cranial irradiation
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Radiation Oncology

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