Skip to main content
Fig. 5 | Radiation Oncology

Fig. 5

From: Differential effects of radiation fractionation regimens on glioblastoma

Fig. 5

Hypofractionated RT regimen improves median survival and inhibits tumor proliferation in syngeneic GB models. a Schematic representation of the in vivo fractionated RT regimens with and without TMZ. b Kaplan–Meier plots show median survival of N = 6 mice per treatment group. c Micrographs of H&E and immunohistochemical staining for Ki67 + proliferation, γH2A.X DNA damage, and CD45 + immune cell infiltration. H&E scale bar = 5 mm, and histological micrographs = 200 µm. d Column graphs show the mean number of positive cells ± SEM per high power field. Five high power field were averaged per mouse. ap < 0.05 vs untreated, bp < 0.05 vs TMZ, cp < 0.05 vs C-RT, dp < 0.05 vs H-RT, ep < 0.05 vs TMZ/C-RT, and fp < 0.05 vs TMZ/H-RT determined by on-way ANOVA with Tukey’s multiple comparison test. nt, no discernible tumor

Back to article page