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Table 1 Characteristics of NPC patients with INN

From: Irradiation-induced nasopharyngeal necrosis (INN) in newly diagnosed nasopharyngeal carcinoma treated by intensity-modulated radiation therapy: clinical characteristics and the influence of treatment strategies

Characteristic Original data set (n = 53) Matched data set n = 212) p
Gender    0.511
 Male 39 (73.6) 165 (77.8)  
 Female 14 (26.4) 47 (22.2)  
Age (y)    0.442
 Median; Range 55; 17–78 55; 18–83  
Comorbidity    
 Anemia 2 (3.8)  
 Hypertension 10 (18.9)  
 Diabetes 7 (13.2)  
Pathology    
Non-keratinizing undifferentiated carcinoma 34 (64.2) 122 (57.5)  
Non-keratinizing differentiated carcinoma 18 (34) 89 (42)  
 Keratinizing carcinoma 1 (1.9) 1 (0.5)  
Necrosis before treatment    
 Yes 7 (13.2)  
 No 46 (86.8)  
HGB before treatment    0.139
 Median; Range 143 (82–181) 142;91–182  
Pseudomembrane during radiation    
 Yes 38 (71.7)  
 No 15 (28.3)  
T staging    0.93
 T1 3 (5.7) 16 (7.5)  
 T2 5 (9.4) 17 (8.0)  
 T3 18 (34) 77 (36.3)  
 T4 27 (50.9) 102 (48.1)  
N staging    0.911
 N0 9 (17.0) 35 (16.5)  
 N1 17 (32.1) 73 (34.4)  
 N2 20 (37.7) 83 (39.2)  
 N3 7 (13.2) 21 (9.9)  
Stage    
 I 0 3 (1.4)  
 II 6 (11.3) 7 (3.3)  
 III 16 (30.2) 82 (38.7)  
 IV 31 (58.5) 120 (56.6)  
Chemotherapy    
 No 16 (30.2) 68 (32.1)  
 Neoadjuvant 6 (11.3) 30 (14.2)  
 Concurrent 34 (64.2) 106 (50.0)  
 Adjuvant 4 (7.5) 8 (3.8)  
Target therapy    
 Yes 10 (18.9) 66 (31.1)  
 No 43 (81.1) 146 (68.9)  
Local boost    
 Yes 8 (15.1) 5 (2.4)  
 No 45 (84.9) 207 (97.6)  
INN stage    
 Early 32 (60.4)  
 Middle 21 (39.6)  
 Serve 0  
  1. NPC nasopharyngeal carcinoma, INN Irradiation-induced nasopharyngeal necrosis, HGB hemoglobin