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Table 3 ROC analysis of the dose-volume histogram parameters of the lung and incidence of radiation pneumonitis of grade 2 or more

From: Predicting factors of symptomatic radiation pneumonitis induced by durvalumab following concurrent chemoradiotherapy in locally advanced non-small cell lung cancer

Dose (Gy) AUC Threshold level (%) Cumulative incidence of G2RP at 6 months p value
 ≥ threshold  < threshold
Lung V50 0.640 5.3 56.8 13.6 0.008
Lung V40 0.686 10.0 57.3 16.7 0.011
Lung V30 0.644 15.7 57.3 26.1 0.048
Lung V20 0.608 23.0 56.4 29.8 0.16
Lung V10 0.566 34.1 52.9 30.0 0.12
Lung V5 0.570 48.2 55.0 30.5 0.07
Mean lung dose 0.640 12.1 54.0 21.1 0.046
Lung Vs5 (ml) 0.533 1364 41.1 37.6 0.62
Initial PTV (ml) 0.679 398 58.3 23.8 0.024
  1. ROC receiver-operating characteristic, G2RP radiation pneumonitis of grade2 or more, Lung Vx percentage of the lung volume exceeding x Gy, Lung Vs5 volume of the lung received less than 5 Gy, PTV planning target volume