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Table 3 BED3 and toxicity characteristics for all patients receiving re-irradiation

From: An algorithm for thoracic re-irradiation using biologically effective dose: a common language on how to treat in a “no-treat zone”

Organ at risk

BED3 composite, mean (range)

Re-SABR toxicity, n (%)

(n = 14)

CRT after SABR toxicity, n (%)

(n = 24)

Total toxicity, n (%)

(n = 38)

Spinal cord

Max: 40 Gy

(5 Gy- 91 Gy)

D1cc: 34 Gy

(1 Gy- 63 Gy)

0 (0%)

0 (0%)

0 (0%)

Trachea

-

0 (0%)

0 (0%)

0 (0%)

Proximal bronchial tree

Max: 133 Gy

(7 Gy- 253 Gy)

D1cc: 108 Gy

(2 Gy- 220 Gy)

0 (0%)

0 (0%)

0 (0%)

Aorta

Max: 120 Gy (22 Gy – 332 Gy)

D1cc: 105 Gy

(15 Gy – 242 Gy)

0 (0%)

0 (0%)

0 (0%)

Pulmonary artery

Max: 114 Gy

(2 Gy – 395 Gy)

D1cc: 101 Gy

(1 Gy – 284 Gy)

0 (0%)

0 (0%)

0 (0%)

Superior vena cava

Max: 89 Gy

(6 Gy – 184 Gy)

D1cc: 77 Gy

(40 Gy – 162 Gy)

0 (0%)

0 (0%)

0 (0%)

Brachial plexus

Max: 16 Gy

(0 Gy – 145 Gy)

D0.2 cc: 13 Gy

(0 Gy – 123 Gy)

Brachial plexopathy

G2 n = 1 (7%)

Brachial plexopathy

n = 0 (0%)

Brachial plexopathy

G2 n = 1 (3%)

Chest wall

Max: 320 Gy

(62 Gy – 568 Gy)

D30cc: 145 Gy

(39 Gy – 339 Gy)

D50cc: 116 Gy

(33 Gy – 308 Gy)

Dermatitis

G1 n = 1 (7%)

CW pain

G1 n = 1 (7%)

G2 n = 1 (7%)

G3 n = 1 (7%)

Rib fracture

G2 n = 3 (21%)

Dermatitis

G1 n = 5 (21%)

G2 n = 1 (4%)

CW pain

G1 n = 2 (8%)

G2 n = 3 (13%)

Rib fracture

G2 n = 2 (8%)

Dermatitis

G1 n = 6 (16%)

G2 n = 1 (3%)

CW pain

G1 n = 3 (8%)

G2 n = 4 (11%)

G3 n = 1 (3%)

Rib fracture

G2 n = 5 (13%)

Esophagus

Mean: 24 Gy

(1 Gy – 67 Gy)

Max: 94 Gy

(5 Gy – 218 Gy)

D30cc: 73 Gy

(1 Gy – 190 Gy)

D50cc: 65 Gy

(1 Gy – 174 Gy)

Fatigue

G1 n = 5 (36%)

G2 n = 1 (7%)

Esophagitis

n = 0 (0%)

Fatigue

G1 n = 10 (42%)

G2 n = 3 (13%)

Esophagitis

G1 n = 11 (46%)

G2 n = 4 (17%)

Fatigue

G1 n = 15 (39%)

G2 n = 4 (11%)

Esophagitis

G1 n = 11 (29%)

G2 n = 4 (1%)

Heart

Mean: 11 Gy

(0 Gy – 58 Gy)

Max: 98 Gy

(1 Gy – 280 Gy)

D5cc: 64 Gy

(0 Gy – 132 Gy)

D40cc: 36 Gy

(0 Gy –111 Gy)

0 (0%)

0 (0%)

0 (0%)

Total lung

Mean: 23 Gy

(6 Gy – 50 Gy)

Max: 434 Gy

(100 Gy – 729 Gy)

V5Gy: 43.6%

(16.2% – 86.9%)

V20Gy: 24.6%

(8.7% – 46.3%)

V35Gy: 18.6%

(3.5% – 39.7%)

Dyspnea

G1 n = 7 (50%)

G2 n = 3 (21%)

G3 n = 1 (7%)

Cough

G1 n = 6 (43%)

Pneumonitis

G2 n = 1 (7%)

G3 n = 1 (7%)

Dyspnea

G1 n = 2 (8%)

G2 n = 2 (8%)

G3 n = 2 (8%)

Cough

G1 n = 8 (33%)

G2 n = 1 (4%)

Pneumonitis

G1 n = 6 (25%)

G3 n = 2 (8%)

Dyspnea

G1 n = 9 (24%)

G2 n = 5 (13%)

G3 n = 3 (8%)

Cough

G1 n = 14 (37%)

G2 n = 1 (3%)

Pneumonitis

G1 n = 6 (16%)

G2 n = 1 (3%)

G3 n = 3 (8%)

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Radiation Oncology

ISSN: 1748-717X

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