Table 6 Relapse free survival before and after the propensity score matched analysis (PS)
Characteristic | RFS univariate pre PS | RFS multivariate pre-PS | RFS univariate post PS | RFS multivariate post-PS | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
1 year | 2 year | p | Exp B | p | 1 year | 2 year | p | Exp-B | p | |
Gender | NS | 0.035 | 0.027 | 0.015 | ||||||
Male | 78.7 | 71 | 78.7 | 71 | 1 | |||||
Female | 90.2 | 86.8 | 94.2 | 90.3 | 0.229 (IC 0.07–0.7488) | |||||
Age | NS | NS | NS | NS | ||||||
< 70 years | 80.6 | 75 | 81.2 | 74.1 | ||||||
> 70 years | 87.7 | 82.2 | 87.7 | 82.2 | ||||||
KPS | NS | NS | NS | NS | ||||||
90–10 | 80.9 | 74.9 | 81.7 | 75.4 | ||||||
70–80 | 82.5 | 74.8 | 82.5 | 74.8 | ||||||
Tobacco use | NS | NS | NS | NS | ||||||
Currently < 10 cigarettes/die | 83 | 75.4 | 83 | 75.4 | ||||||
Currently 10–20 cigarettes/die | 87 | 77.6 | 86.5 | 76.6 | ||||||
Currently > 20 cigarettes/die | 78.3 | 73.8 | 78.3 | 73.7 | ||||||
Stopped smoking > 5 years | 82.5 | 78.7 | 81.8 | 77.9 | ||||||
Never smoked | 79.5 | 72.9 | 82.3 | 74.9 | ||||||
Alcohol | NS | NS | NS | NS | ||||||
Currently | 85.8 | 79 | 85.7 | 78.7 | ||||||
Past | 76.7 | 63.8 | 76.7 | 63.8 | ||||||
Never | 78.4 | 76.2 | 78.7 | 76.3 | ||||||
Stage T | NS | NS | NS | NS | ||||||
T1-2 | 82.5 | 77.9 | 83.6 | 78.9 | ||||||
T3-4 | 80.9 | 72.1 | 80.9 | 72.1 | ||||||
Stage N | NS | NS | NS | NS | ||||||
0 | 88.9 | 82.1 | 88.9 | 82.1 | ||||||
1 | 91.1 | 85 | 91.1 | 85 | ||||||
2 | 79.8 | 74.2 | 80.4 | 74.5 | ||||||
3 | 53.3 | 26.7 | 26.7 | 26.7 | ||||||
Stage of disease | NS | NS | NS | NS | ||||||
II | 100 | 100 | 100 | 100 | ||||||
III | 83.4 | 79.5 | 83.4 | 79.5 | ||||||
IV | 80.4 | 72.8 | 81 | 73.1 | ||||||
Site of disease | NS | NS | NS | NS | ||||||
Oropharynx | 84.9 | 78.8 | 85.9 | 79.4 | ||||||
Hypopharynx | 84 | 68.5 | 84 | 68.5 | ||||||
Larynx | 63 | 63 | 63 | 63 | ||||||
RT technique | NS | NS | NS | NS | ||||||
IMRT/VMAT | 76.7 | 69.5 | 77.5 | 70 | ||||||
Helical IMRT | 92.3 | 82.6 | 92.3 | 86.4 | ||||||
Type of CHT | NS | NS | NS | NS | ||||||
1w-CDDP | 85.2 | 78.9 | 75.2 | 67.6 | ||||||
3w-CDDP | 74.3 | 67.5 | 85.2 | 78.9 | ||||||
Total CDDP/m2 | NS | NS | NS | NS | ||||||
< 200 mg/m2 | 66.7 | 53.3 | 48 | 48 | ||||||
200–250 mg/m2 | 85.9 | 85.9 | 93.3 | 93.3 | ||||||
> 250 mg/m2 | 82.3 | 75.6 | 82.9 | 76 | ||||||
CDDP interruption | NS | NS | NS | NS | ||||||
Yes | 79.6 | 76.2 | 79.8 | 76.3 | ||||||
No | 83.8 | 74.2 | 84.7 | 74.7 | ||||||