Table 5 One- and two year overall (OS) survival before and after the propensity score matched analysis (PS)
Characteristic | OS univariate pre-PS | OS multivariate pre-PS | OS univarite after PS | OS multivariate after PS | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
1 year | 2 year | p | Exp B | p | 1 year | 2 year | Exp B | |||
Gender | 0.004 | NS | 0.022 | 0.034 | ||||||
Male | 95 | 83.7 | 95.9 | 80.9 | 1 | |||||
Female | 100 | 100 | 100 | 94.9 | 0.217 | |||||
Age | NS | NS | NS | NS | ||||||
< 70 years | 96.3 | 88.2 | 96.2 | 84.7 | ||||||
> 70 years | 100 | 85.9 | 100 | 81.2 | ||||||
KPS | NS | NS | NS | NS | ||||||
90–100 | 96.3 | 89.9 | 96.1 | 84 | ||||||
70–80 | 98 | 83.4 | 98.1 | 83.7 | ||||||
Tobacco use | NS | NS | NS | NS | ||||||
Currently < 10 cig/die | 94.1 | 94.1 | 94.1 | 94.1 | ||||||
Currently 10–20 cig/die | 96.8 | 90.1 | 96.7 | 89.7 | ||||||
Currently > 20 cig/die | 97.1 | 75.3 | 97.1 | 75.3 | ||||||
Stopped > 5 years | 96.6 | 88.2 | 96.6 | 84.7 | ||||||
Never smoked | 98 | 93 | 97.8 | 83.5 | ||||||
Alcohol | NS | NS | NS | NS | ||||||
Currently | 95.4 | 85.3 | 95.3 | 85.1 | ||||||
Past | 100 | 82.4 | 100 | 82.4 | ||||||
Never | 98 | 93.1 | 97.9 | 77.9 | ||||||
Stage T | NS | NS | NS | NS | ||||||
T1-2 | 96.3 | 88.4 | 96 | 83.2 | ||||||
T3-4 | 97.5 | 87.4 | 97.5 | 84.9 | ||||||
Stage N | NS | NS | 0.010 | 0.047 | ||||||
0 | 100 | 93.3 | 100 | 93.3 | 1 | |||||
1 | 95.7 | 91.3 | 95.7 | 91.3 | 0.780 (IC 0.09–6.773) | 0.822 | ||||
2 | 97.4 | 86.8 | 97.3 | 82.3 | 2.933 (IC 0.582–14.768) | 0.192 | ||||
3 | 80 | 80 | 60 | 60 | 14.936 (IC 1.665–133.985) | 0.016 | ||||
Stage of disease | NS | NS | NS | NS | ||||||
II | 100 | 100 | 100 | 100 | ||||||
III | 96.8 | 79.5 | 96.8 | 79.5 | ||||||
IV | 96.8 | 89.6 | 96.6 | 84.7 | ||||||
Site of disease | 0.04 | 0.027 | 0.034 | 0.007 | ||||||
Oropharynx | 98.2 | 92.3 | 1 | 99.1 | 87 | 1 | ||||
Hypopharynx | 88 | 75.1 | 6.238 (IC 1.549–25.4) | 0.10 | 88 | 75.1 | 5.5 (IC 2.1.918–16.03) | 0.002 | ||
Larynx | 95.5 | 80.6 | 1.399 (IC 0.27–7.236 | 0.689 | 95.5 | 80.6 | 2.02 (IC 0.586–7.481) | 0.255 | ||
RT technique | NS | ns | NS | ns | ||||||
IMRT/VMAT | 94.9 | 85.9 | 94.7 | 80 | ||||||
Helical IMRT | 100 | 89.7 | 100 | 89.7 | ||||||
Type of CHT | 0.026 | 0.007 | NS | ns | ||||||
1w CDDP | 96.4 | 84.6 | 1 | 97.8 | 82.9 | |||||
3w CDDP | 98 | 95.4 | 0.006 (0.000–0.241) | 96.4 | 84.6 | |||||
Total CDDP/m2 | NS | 0.006 | NS | ns | ||||||
≤ 200 mg/m2 | 95.7 | 87.6 | 1 | 90 | 58.3 | |||||
> 200–250 mg/m2 | 100 | 88.4 | 0.567 (IC 0.123–2.627 | 0.469 | 100 | 78.6 | ||||
> 250 mg/m2 | 93.1 | 88.7 | 235.838 (IC 7.565–7352.1) | 0.002 | 97 | 86.7 | ||||
CDDP interruption | NS | ns | NS | ns | ||||||
Yes | 97.5 | 87.6 | 97.3 | 85.7 | ||||||
No | 96.4 | 88.2 | 96.3 | 82.8 | ||||||