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Table 3 Treatment in relation to chemotherapy schedule

From: Three weekly versus weekly concurrent cisplatin: safety propensity score analysis on 166 head and neck cancer patients

Treatment characteristic

1w-CDDP (N.114)

3w-CDDP (N.52)

p

Entire series (%)

Cumulative CDDP/m2 dose

0.000

 

 ≤ 200 mg/m2

82 (71.9%)

14 (26.9%)

 

96 (57.8%)

 200–250 mg/m2

29 (25.4%)

12 (23.1%)

 

41 (24.7%)

 > 250 mg/m2

3 (2.6%)

26 (50%)

 

29 (17.5%)

Median CDDP/m2

175.9 mg/m2

248.1 mg/m2

0.026

 

CDDP interruption

 Yes

64 (56.1%)

18 (34.6%)

0.012

82 (49.4%)

 No

50 (43.9%)

34 (65.4%)

 

84 (50.6%)

RTT dose

0.000

 

 69 Gy

10 (8.8%)

0

 

10 (6%)

 > 69 Gy and < 70 Gy

47 (41.2%)

0

 

47 (28%)

 70 Gy

57 (50%)

52(100%)

 

109 (66%)

RTT dose/fraction

0.000

 

 2.3 Gy/fr

10 (8.8%)

0

 

10 (6%)

 2.1–2.2 Gy/fr

47 (41.2%)

0

 

47 (28%)

 2 Gy/fr

57 (50%)

52(100%)

 

109 (66%)

RTT technique

0.000

 

 3D

3 (2.6%)

4 (7.7%)

 

7 (4.2%)

 IMRT (VMAT)

53 (46.5%)

48 (92.3%)

 

101 (60.8%)

 Helical IMRT

58 (50.9%)

0 (0%)

 

58 (34.9%)

  1. 1w-CDDP weekly Cisplatin, 3w-CDDP three-weekly Cisplatin, RTT radiotherapy, IMRT intensity modulated radiation therapy, VMAT volumetric modulated arch therapy, fr fraction