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Table 2 Univariate analysis of the risk factors related to distant metastasis in de novo NPC patients

From: Selectively recommend 18F-FDG PET/CT for patients with de novo nasopharyngeal carcinoma in endemic areas

  DM positive
N = 244(%)
DM negative
N = 4225(%)
OR (95%CI) P
Gender     0.000
 Male 206 (84.43) 3063 (72.50) 1
 Female 38 (15.57) 1162 (27.50) 0.486 (0.342–0.692)
Age     0.062
  ≤ 50 130 (53.28) 1992 (47.15) 1
  > 50 114 (46.72) 2233 (52.85) 1.278 (0.987–1.656)
T stage     0.000
 T1 25 (10.25) 795 (18.82) 1 0.000
 T2 28 (11.48) 765 (18.11) 1.164 (0.673–2.014) 0.587
 T3 81 (33.20) 1546 (36.59) 1.666 (1.055–2.630) 0.028
 T4 110 (45.08) 1119 (26.48) 3.126 (2.006–4.872) 0.000
N stage     0.000
 N0 6 (2.46) 369 (8.73) 1 0.000
 N1 25 (10.25) 1568 (37.11) 0.981 (0.399–2.407) 0.966
 N2 94 (38.52) 1475 (34.91) 3.919 (1.704–0.017) 0.001
 N3 119 (48.77) 813 (19.24) 9.002 (3.928–20.629) 0.000
Plasma EBV DNA     0.000
 Low* 127 (52.05) 3426 (81.09) 1
 High** 117 (47.95) 799 (18.91) 3.950 (3.038–5.137)
Group     0.001
 CWU 157 (64.34) 3141 (74.34) 1
 PET 87 (35.66) 1084 (25.66) 1.606 (1.225–2.1.5)
  1. DM, distant metastasis
  2. *Low EBV DNA level of < 14,650 copies/ml
  3. **High EBV DNA level of ≥ 14,650 copies/ml