Table 2 Univariate analysis of the risk factors related to distant metastasis in de novo NPC patients
|  | DM positive N = 244(%) | DM negative N = 4225(%) | OR (95%CI) | P |
|---|---|---|---|---|
Gender | Â | Â | Â | 0.000 |
 Male | 206 (84.43) | 3063 (72.50) | 1 | – |
 Female | 38 (15.57) | 1162 (27.50) | 0.486 (0.342–0.692) | – |
Age | Â | Â | Â | 0.062 |
  ≤ 50 | 130 (53.28) | 1992 (47.15) | 1 | – |
  > 50 | 114 (46.72) | 2233 (52.85) | 1.278 (0.987–1.656) | – |
T stage | Â | Â | Â | 0.000 |
 T1 | 25 (10.25) | 795 (18.82) | 1 | 0.000 |
 T2 | 28 (11.48) | 765 (18.11) | 1.164 (0.673–2.014) | 0.587 |
 T3 | 81 (33.20) | 1546 (36.59) | 1.666 (1.055–2.630) | 0.028 |
 T4 | 110 (45.08) | 1119 (26.48) | 3.126 (2.006–4.872) | 0.000 |
N stage | Â | Â | Â | 0.000 |
 N0 | 6 (2.46) | 369 (8.73) | 1 | 0.000 |
 N1 | 25 (10.25) | 1568 (37.11) | 0.981 (0.399–2.407) | 0.966 |
 N2 | 94 (38.52) | 1475 (34.91) | 3.919 (1.704–0.017) | 0.001 |
 N3 | 119 (48.77) | 813 (19.24) | 9.002 (3.928–20.629) | 0.000 |
Plasma EBV DNA | Â | Â | Â | 0.000 |
 Low* | 127 (52.05) | 3426 (81.09) | 1 | – |
 High** | 117 (47.95) | 799 (18.91) | 3.950 (3.038–5.137) | – |
Group | Â | Â | Â | 0.001 |
 CWU | 157 (64.34) | 3141 (74.34) | 1 | – |
 PET | 87 (35.66) | 1084 (25.66) | 1.606 (1.225–2.1.5) | – |