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Table 4 Univariate analysis of treatment outcomes of the re-irradiation SABR group

From: Treatment outcomes of re-irradiation using stereotactic ablative radiotherapy to lung: a propensity score matching analysis

Variable (comparison vs reference)

Local control

Distant metastasis–free survival

Progression–free survival

Overall survival

HR

95% CI

P value

HR

95% CI

P value

HR

95% CI

P value

HR

95% CI

P value

Age (> 75 years vs ≤ 75)

1.239

0.276–5.556

0.780

1.264

0.423–3.782

0.675

1.108

0.401–3.062

0.844

3.287

0.843–12.82

0.087

Tumor size (> 2 vs ≤ 2 cm)

0.606

0.135–2.717

0.513

1.085

0.363–3.242

0.884

0.637

0.229–1.769

0.387

2.424

0.622–9.441

0.202

Location (lower lobe vs upper and middle)

0.952

0.213–4.267

0.949

0.944

0.315–2.831

0.918

0.776

0.279–2.156

0.626

2.607

0.669–10.16

0.168

Tumor centrality (central vs peripheral)

0.418

0.050–3.474

0.419

0.751

0.206–2.741

0.664

0.543

0.153–1.929

0.345

0.569

0.115–2.822

0.490

Histology (squamous cell carcinoma vs others)

4.094

0.788–21.27

0.094

0.932

0.312–2.788

0.900

1.325

0.478–3.674

0.589

1.745

0.501–6.082

0.382

Smoking (≥ 10 vs < 10 pack-year)

1.393

0.270–7.203

0.692

1.841

0.503–6.732

0.356

1.839

0.582–5.811

0.299

2.164

0.458–10.23

0.330

Concurrent chemotherapy at first RT course (yes vs no)

–

–

–

0.322

0.041–2.515

0.280

0.250

0.033–1.913

0.182

-

-

-

RT technique of first course (SABR vs 3D-CRT)

2.975

0.357–24.77

0.313

4.056

0.836–19.68

0.082

4.847

1.073–21.91

0.040

9.167

1.062–79.08

0.044

Any treatment between RT courses (yes vs no)

2.436

0.471–12.59

0.288

1.984

0.535–7.359

0.306

1.267

0.357–4.506

0.714

5.686

1.265–25.55

0.023

Treatment interval between RT courses (> 12 vs ≤ 12 months)

1.272

0.246–6.569

0.774

0.665

0.203–2.178

0.501

0.981

0.311–3.096

0.974

1.517

0.319–7.226

0.601

PTV volume (> 50 vs ≤ 50 cm3)

3.052

0.574–16.23

0.191

1.175

0.249–5.545

0.839

1.926

0.523–7.093

0.324

4.53

0.802–25.60

0.087

Age-adjusted Charlson Comorbidity Index (≥ 10 vs < 10)

–

–

–

0.485

0.062–3.812

0.491

0.328

0.042–2.530

0.285

0.988

0.121–8.078

0.991

Cumulative BED10 (≥ 120 Gy vs < 120)

2.477

0.298–20.59

0.401

0.315

0.099–1.001

0.050

0.602

0.212–1.715

0.342

0.371

0.106–1.295

0.120

  1. SABR, stereotactic ablative body radiotherapy; HR, hazard ratio; CI, confidence interval; RT, radiotherapy; 3D-CRT, 3-dimensional conformal radiation therapy; PTV, planning target volume; BED10, biologically equivalent dose with α/β of 10
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Radiation Oncology

ISSN: 1748-717X

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