Table 1 Patients’ characteristics of 581 locally advanced ESCC patients and patients’ clinicopathological characteristics according to chemotherapy
Clinicopathologic variable | Total(N) | CRT (n = 317) | RT (n = 264) | p value | |
|---|---|---|---|---|---|
Age (years) | < 0.001 | ||||
65–74 | 316 (54.4%) | 245 (42.2%) | 71 (12.2%) | ||
≥ 75 | 265 (45.6%) | 72 (12.4%) | 193 (33.2%) | ||
Gender | 0.005 | ||||
Male | 373 (64.2%) | 220 (37.9%) | 153 (26.3%) | ||
Female | 208 (35.8%) | 97 (16.7%) | 111 (19.1%) | ||
Weight loss | 0.023 | ||||
Yes | 281 (48.4%) | 167 (28.7%) | 114 (19.6%) | ||
No | 300 (51.6%) | 150 (25.8%) | 150 (25.8%) | ||
RT dose (Gy) | 0.567 | ||||
≤ 58.8 | 101 (17.4%) | 52 (9.0%) | 49 (8.4%) | ||
> 58.8 | 480 (82.6%) | 265 (45.6%) | 215 (37.0%) | ||
Tumor location | 0.118 | ||||
Cervical | 37 (6.4%) | 26 (4.5%) | 11 (1.9%) | ||
Upper thoracic | 133 (22.9%) | 78 (13.4%) | 55 (9.5%) | ||
Middle thoracic | 338 (58.2%) | 176 (30.3%) | 162 (27.9%) | ||
Lower thoracic | 73 (12.6%) | 37 (6.4%) | 36 (6.2%) | ||
Tumor length (cm) | 0.010 | ||||
≤ 5.8 | 344 (59.2%) | 172 (29.6%) | 172 (29.6%) | ||
> 5.8 | 237 (40.8%) | 145 (25.0%) | 92 (15.8%) | ||
Tumor thickness (cm) | 0.989 | ||||
≤ 1.2 | 232 (39.9%) | 126 (21.7%) | 106 (18.2%) | ||
> 1.2 | 349 (60.1%) | 191 (32.9%) | 158 (27.2%) | ||
T stage | 0.005 | ||||
T2 | 41 (7.1%) | 16 (2.8%) | 25 (4.3%) | ||
T3 | 299 (51.5%) | 152 (26.2%) | 147 (25.3%) | ||
T4 | 241 (41.5%) | 149 (25.6%) | 92 (15.8%) | ||
N stage | 0.030 | ||||
N0 | 190 (32.7%) | 91 (15.7%) | 99 (17.0%) | ||
N1 | 259 (44.6%) | 143 (24.6%) | 116 (20.0%) | ||
N2 | 111 (19.1%) | 67 (11.5%) | 44 (7.6%) | ||
N3 | 21 (3.6%) | 16 (2.8%) | 5 (0.9%) | ||
TNM stage | 0.001 | ||||
Stage II | 148 (25.5%) | 63 (10.8%) | 85 (14.6%) | ||
Stage III | 180 (31.0%) | 96 (16.5%) | 84 (14.5%) | ||
Stage IVA | 253 (43.5%) | 158 (27.2%) | 95 (16.4%) | ||
Year of diagnosis | 0.059 | ||||
2007–2017 | 404 (69.5%) | 210 (36.1%) | 194 (33.4%) | ||
2018–2020 | 177 (30.5%) | 107 (18.4%) | 70 (12.0%) | ||
PNI | 0.048 | ||||
≤ 41.7 | 88 (15.1%) | 39 (6.7%) | 49 (8.4%) | ||
> 41.7 | 493 (84.9%) | 278 (47.8%) | 215 (37.0%) | ||
NLR | 0.025 | ||||
≤ 4.44 | 517 (89.0%) | 291 (50.1%) | 226 (38.9%) | ||
> 4.44 | 64 (11.0%) | 26 (4.5%) | 38 (6.5%) | ||
PLR | 0.278 | ||||
≤ 180 | 451 (77.6%) | 252 (43.4%) | 199 (34.3%) | ||
> 180 | 130 (22.4%) | 65 (11.2%) | 65 (11.2%) | ||
LMR | 0.426 | ||||
≤ 3.73 | 246 (42.3%) | 129 (22.2%) | 117 (20.1%) | ||
> 3.73 | 335 (57.7%) | 188 (32.4%) | 147 (25.3%) | ||
SII | 0.149 | ||||
≤ 918 | 482 (83.0%) | 270 (46.5%) | 212 (36.5%) | ||
> 918 | 99 (17.0%) | 47 (8.1%) | 52 (9.0%) |