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Table 2 Overview of applied TCP and NTCP models

From: Investigating the potential of proton therapy for hypoxia-targeted dose escalation in non-small cell lung cancer

Model

Type

Endpoint

References

TCP

EUD

Tumor control

Okunieff et al. [22], Chaikh and Balosso [23]

NTCP

Sigmoid

Symptomatic radiation pneumonitis

Appelt et al. [24]

NTCP

LKB

Radiation pneumonitis (grade ≥ 2)

Tucker et al. [25]

NTCP

Logistic

Severe acute esophagitis (grade ≥ 2)

Huang et al. [26]

NTCP

Logistic

Acute esophageal toxicity (grade ≥ 2)

Wijsman et al. [27]

NTCP

LKB

Radiation induced esophagitis (grade ≥ 2)

Wang et al. [28]

NTCP

Relative seriality

Death due to heart failure

Gagliardi et al. [29]

  1. One TCP and six NTCP models were chosen based on multi-institutional cohorts, external validation and treatment modality. LKB: Lyman-Kutcher-Burman model, EUD: Equivalent uniform dose model