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Fig. 2 | Radiation Oncology

Fig. 2

From: Investigating the potential of proton therapy for hypoxia-targeted dose escalation in non-small cell lung cancer

Fig. 2

Exemplary voxel-wise TCP calculation from Patient 6 for the conventional proton plan with uniform dose prescription (A,B) and patient-specific escalated dose (22%) to the hypoxic tumor volume (C). PTV contours in orange, the hypoxic region GTVhypoxic in black. Taking into account hypoxia information and its influence on TCP, locoregional losses can be observed (B) compared to the planned TCP (A) where OER is assumed to be consistently 1 throughout the target. The dose escalation (C) counteracts the increased radioresistance caused by hypoxia by increasing the dose to the radioresistant area and thus recovers TCP

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