Fig. 1

TCP for each patient in the cohort calculated for the primary CTV. Losses in TCP due to hypoxia are shown in the reduced effective TCPs for the uniform dose prescription proton plans. Escalating the dose restores the TCP to what was originally planned for. The loss in effective TCP for uniform dose plans compared to the initial plan was correlated to the degree of hypoxia in the GTVhypoxic (grayscale colorbar)