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Table 2 Univariate and multivariate analyses of cardiovascular-pulmonary disease-related mortality using a Fine-Gray hazard model

From: Effects of postoperative radiotherapy on cardiovascular-pulmonary disease mortality in patients with stage IIIA-N2 resected NSCLC: analysis of the SEER database

Variable name

HR

95% CI for HR

p-value

Univariate analysis (N = 2760)

   

Age, years ( > = 60 vs. < 60)

1.60

1.08

2.38

0.020*

Sex (Male vs. Female)

1.65

1.18

2.32

0.004*

Race

    

Black

Reference

   

White

1.15

0.66

2.00

0.618

Others or unknown

0.46

0.17

1.20

0.111

Year of diagnosis

    

2004–2007

Reference

   

2008–2011

0.67

0.46

0.98

0.037*

2012–2015

0.31

0.19

0.48

< 0.001*

Laterality (Left vs. Right)

1.18

0.85

1.64

0.330

Primary site

    

Main bronchus

Reference

   

Upper lobe

0.85

0.21

3.48

0.820

Middle lobe

0.47

0.09

2.59

0.385

Lower lobe,

0.96

0.23

3.96

0.950

Overlapping lesion of lung

0.68

0.09

4.85

0.696

Tumor size, mm ( < = 40 vs. > 40)

1.09

0.77

1.54

0.628

Histologic type

    

Adenocarcinoma

Reference

   

Squamous cell carcinoma

1.93

1.34

2.78

< 0.001*

Others

1.03

0.59

1.79

0.919

Grade

    

Well differentiated

Reference

   

Moderately differentiated

0.87

0.37

2.03

0.750

Poorly differentiated

1.13

0.49

2.60

0.778

Undifferentiated; anaplastic

1.16

0.32

4.11

0.823

Unknown

0.85

0.29

2.47

0.771

Surgical procedure (Pneumonectomy vs. Lobectomy)

1.26

0.75

2.12

0.374

T stage (sixth edition)

    

T1

Reference

   

T2

0.81

0.57

1.15

0.244

T3

0.71

0.35

1.44

0.342

Chemotherapy (No vs. Yes)

2.04

1.35

3.08

0.001*

Metastatic lymph node ( < = 4 vs. > 4)

1.18

0.81

1.70

0.395

Positive lymph node ratio (%) ( < = 50 vs. > 50)

0.79

0.54

1.14

0.204

PORT (Yes vs. No)

1.07

0.77

1.48

0.703

Multivariate analysis (N = 2760)

    

Age, years ( > = 60 vs. < 60)

1.36

0.87

2.14

0.179

Sex (Male vs. Female)

1.57

1.06

2.32

0.026*

Year of diagnosis

    

2004–2007

Reference

   

2008–2011

0.60

0.40

0.91

0.015*

2012–2015

0.29

0.18

0.49

< 0.001

Histologic type

    

Adenocarcinoma

Reference

   

Squamous cell carcinoma

1.70

1.13

2.54

0.010*

Others

0.84

0.46

1.53

0.569

Chemotherapy (No vs. Yes)

1.41

0.88

2.25

0.154

PORT (Yes vs. No)

1.18

0.82

1.71

0.377

  1. Model adjusted for multivariate analysis: Age, Year of diagnosis, Sex, Histologic type, Chemotherapy, PORT.
  2. HR, hazard ratio; CI, confidence interval; PORT, postoperative radiotherapy
  3. *P < 0.05 was considered significant and marked in bold
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Radiation Oncology

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