Table 1 Patient characteristics

Histology

 Adeno-Ca

83

 Squamous Cell Ca

80

 Other

17

cT-category

 T1

18

 T2

35

 T3

53

 T4

74

Pattern of lymph node spread by EBUS/PET: Discovery group 1 of patients with EBUS-TBNA samples from all echelons: n = 104

 1.1: echelon-1, 2, 3: negative, negative, negative (EBUS/PET)

4/4

 1.2: echelon-1, 2, 3: positive, negative, negative (EBUS/PET)

31/21

 1.3: echelon-1, 2, 3: positive, positive, negative (EBUS/PET)

52/37

 1.4: echelon-1, 2, 3: negative, positive, negative (EBUS/PET)

3/2

 1.5.1: echelon-1, 2, 3: negative, negative, positive (EBUS/PET)

0/1

 1.5.2: echelon-1, 2, 3: positive, negative, positive (EBUS/PET)

1/4

 1.5.3: echelon-1, 2, 3: negative, positive, positive (EBUS/PET)

0/1

 1.6: echelon-1, 2, 3: positive, positive, positive (EBUS/PET)

13/34

Pattern of lymph node spread by EBUS/PET: Validation group 2 of patients with EBUS-TBNA samples for which EBUS samples are missing at echelon-1: n = 37

 2.1: echelon-2, 3: negative, negative (EBUS/PET)

15/10

 2.2: echelon-2, 3: positive, negative (EBUS/PET)

17/15

 2.3: echelon-2, 3: negative, positive (EBUS/PET)

1/2

 2.4: echelon-2, 3: positive, positive (EBUS/PET)

4/10

Pattern of lymph node spread by PET/ EBUS: Validation group 3 of the remaining patients with EBUS-TBNA samples for which EBUS samples are missing at echelon-3: n = 39

 3.1: echelon-1, 2: negative/missing, negative (EBUS/PET)

3/2

 3.2: echelon-1, 2: positive, negative (EBUS/PET)

12/9

 3.3: echelon-1, 2: positive, positive (EBUS/PET)

14/19

 3.4: echelon-1, 2: negative/missing, positive (EBUS/PET)

4/3

 3.5: echelon-2: Patients with EBUS-untested echelon-2

6

RT-intent

 Definitive RT/CTx

114

 Neoadjuvant RT/CTx

66

Laterality of the primary tumor

 Left-sided

83

 Right-sided

93

 Bilateral primaries

4

Tumor localization

 Upper or middle lobe alone

63

 Lower lobe alone

27

 Centrally or more than one lobe

90

 Median

62.9

 Range

43.6–84.0