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Table 4 Mean Score values for the multi-item QOL scales and single items for the EORTC QLQ-OPT30

From: Quality of life and treatment-related burden during ocular proton therapy: a prospective trial of 131 patients with uveal melanoma

EORTC QLQ-OPT30

T0

T1

T2

T3

Friedman Test

p (T0:T1)

p (T1:T2)

p (T2:T3)

p (T0:T3)

Multi-Item-Scales

Ocular irritation

12.42 ± 14.73

31.62 ± 18.47

27.55 ± 19.24

22.71 ± 18.99

< 0.001

< 0.001

0.001

0.026

< 0.001

Visual impairment

15.33 ± 18.51

24.46 ± 23.87

21.84 ± 24.67

22.85 ± 23.25

< 0.001

< 0.001

0.158

0.272

< 0.001

Worry about recurrence

61.68 ± 29.65

56.88 ± 29.79

48.81 ± 30.82

46.18 ± 28.59

< 0.001

0.031

< 0.001

0.815

< 0.001

Problems with exterior aspect

6.32 ± 18.08

23.71 ± 27.05

25.68 ± 27.13

21.86 ± 25.96

< 0.001

< 0.001

0.718

0.464

< 0.001

Functional problems with visual impairment

13.32 ± 19.38

22.67 ± 22.56

22.92 ± 23.92

26.00 ± 22.6

< 0.001

< 0.001

0.954

0.010

< 0.001

Functional problems with treated eye

25.64 ± 21.48

29.18 ± 22.37

30.83 ± 23.39

33.11 ± 22.18

< 0.001

0.001

0.952

0.157

< 0.001

Problems with driving

21.52 ± 24.99

26.15 ± 30.71

26.64 ± 29.13

35.78 ± 30.7

< 0.001

0.009

0.633

0.030

< 0.001

Single Items

Headache

14.97 ± 24.50

16.15 ± 24.64

16.24 ± 26.12

20.44 ± 29.3

0.356

    

Problems with reading

33.33 ± 35.83

41.93 ± 30.24

40.62 ± 29.8

42.68 ± 29.24

0.010

    
  1. QOL: quality of life; EORTC QLQ-OPT30: European Organization for Research and Treatment of Cancer QOL questionnaire-ophthalmic oncology module; T0: before clip-surgery; T1: between clip-surgery and proton therapy; T2: after proton therapy; and T3: three months after treatment; Bold font: In cases where the Friedman pre-test showed significance, changes between two assessment points are considered significant for p-values ≤ 0.003