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Table 2 The main characteristics of the included studies

From: The impact of pelvic radiotherapy on the gut microbiome and its role in radiation-induced diarrhoea: a systematic review

First Author

year

Type of study

Type of disease

No. of subjects

No. of healthy controls

RT dose (Gy)

Analysis technique microbiome

sample

Evaluation criteria of diarrhea

No of patients reporting diarrhoea

Before–after design

CCRT* or not

No. of testing time point

testing time point

Mitra

2020

Prospective cohort

Cervical cancer

35

0

–

16 s-rRNA

Stool

EPIC

–

Yes

Yes

4

Before RT

Wang

2019

Prospective cohort

Cervical cancer

18

0

50.4 Gy

16 s-rRNA

Stool

–

10

No

No

2

One day before RT,

Reis Ferreira

2019

Prospective cohort

Prostate cancer

32

6

60–74 Gy

16 s-rRNA

Stool sigmoid /rectum mucosa

RTOG

–

Yes

–

6

Before RT,

Medrano

2017

Prospective cohort

Cervical cancer

20

20

–

16 s-rRNA

Rectum

EPIC

–

Yes

–

4

Before RT,

Wang

2015

Retrospective study

Cervical cancer; anal canal cancer and rectal cancer

11

4

44-50 Gy

16 s-rRNA

Stool

CTCAE

5

Yes

No

2

Before RT,

Nam

2013

Prospective cohort

Cervical cancer and endometrial cancer

9

6

50.4 Gy

16 s-rRNA

Stool

Diarrhea Indices

–

Yes

–

4

Before RT,

Manichanh

2008

Prospective cohort

Cervical cancer, endometrial cancer and rectal cancer

10

5

43.2–54 Gy

16 s-rRNA

Stool

CTCAE

6

Yes

–

4

Before RT,

Cuzzolin

1992

Prospective cohort

Gynecologic cancer

15

15

40 Gy

Bacterial culture and counting

Stool

–

–

Yes

No

5

Before RT,

  1. EPIC The Expanded Prostate Cancer Index Composite questionnaire, CTCAE common terminology criteria for adverse events, RT radiotherapy, CCRT concurrent chemoradiotherapy, RT radiation therapy
  2. – Not mentioned in the text