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Table 1 Clinical characteristics of five neuroendocrine carcinoma patients with a history of radical radiotherapy for nasopharyngeal carcinoma

From: Pathological and genomic phenotype of second neuroendocrine carcinoma during long-term follow-up after radical radiotherapy for nasopharyngeal carcinoma

  Patient 1 Patient 2 Patient 3 Patient 4 Patient 5
Age 59 67 50 56 49
Gender Male Male Male Male Male
Year diagnosed NPC 2008 2007 2005 2010 2002
NPC stage T3N2M0 T3N1M0 T3N0M0 T2N0M0 *
Treatment of NPC
RT 2008 2007 2005 2010 2002
70 Gy/35F 70 Gy/35F Radical RT 70 Gy/35F Yes*
2D 2D 2D 2D 2D
CT DDP DDP DDP DDP Yes*
Date diagnosed NEC 2018/09/20 2020/03/09 2019/01/31 2020/04/29 2020/09/01
Sites of NEC Left nasal cavity Right hard palate Left nasal cavity Right nasal cavity-skull base Left ethmoidal sinus
Treatment of NEC
ST 2020/03/06 2019/02/19 2020/04/23 2020/08/24
RT GTV 70 Gy/33F GTV 66 Gy/30F GTV 64 Gy/30F
2018/10/23 2019/04/08 2020/05/25
IMRT IMRT IMRT
CT VP VP VP VP GP
PFS 6 m 3 m 4 m Censored Censored
OS 9 m 3 m 9 m Alive Alive
  1. NEC, neuroendocrine carcinoma; NPC, nasopharyngeal carcinoma; OS, overall survival; IMRT, intensity modulated radiation therapy; RT, radiotherapy; CT, chemotherapy; ST, surgery therapy; GP, gemcitabine + DDP (cisplatin); VP, VP16 (etoposide) + DDP (cisplatin); 2D, two-dimensional radiotherapy
  2. –, not performed; *, no exact details