Table 5 Univariate and multivariate Cox regression analyses of PTBE development in patients with intracranial meningioma after LINAC-based radiation treatment after propensity score matching based on patient sex, patient age, tumor location, GTV, and BED
Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
Variable | HR (95% CI) | p | HR (95% CI) | p |
Sex | ||||
Male | Reference | Reference | ||
Female | 0.83 (0.23–2.98) | 0.774 | 0.44 (0.08–2.37) | 0.339 |
Age (per 1 year increase) | 1.03 (0.97–1.08) | 0.357 | 1.02 (0.95–1.09) | 0.671 |
Location | 0.98 (0.67–1.45) | 0.932 | 1.09 (0.67–1.78) | 0.732 |
GTV (per 1 cc increase) | 1.05 (0.99–1.11) | 0.095 | 1.09 (1.01–1.17) | 0.028 |
BED (α/β = 3) (per 1 Gy increase) | 0.99 (0.96–1.02) | 0.592 | 1.02 (0.99–1.06) | 0.210 |
Classification of mean skull HU | ||||
Hypothetical normal | Reference | Reference | ||
Hypothetical osteopenia | 2.90 (0.29–29.30) | 0.368 | 5.67 (0.40–81.37) | 0.202 |
Hypothetical osteoporosis | 3.88 (1.02–14.81) | 0.047 | 5.36 (1.06–27.12) | 0.042 |