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Table 5 Univariate and multivariate Cox regression analyses of PTBE development in patients with intracranial meningioma after LINAC-based radiation treatment after propensity score matching based on patient sex, patient age, tumor location, GTV, and BED

From: Effect of osteoporotic conditions on the development of peritumoral brain edema after LINAC-based radiation treatment in patients with intracranial meningioma

  Univariate analysis Multivariate analysis
Variable HR (95% CI) p HR (95% CI) p
Sex     
 Male Reference   Reference  
 Female 0.83 (0.23–2.98) 0.774 0.44 (0.08–2.37) 0.339
Age (per 1 year increase) 1.03 (0.97–1.08) 0.357 1.02 (0.95–1.09) 0.671
Location 0.98 (0.67–1.45) 0.932 1.09 (0.67–1.78) 0.732
GTV (per 1 cc increase) 1.05 (0.99–1.11) 0.095 1.09 (1.01–1.17) 0.028
BED (α/β = 3) (per 1 Gy increase) 0.99 (0.96–1.02) 0.592 1.02 (0.99–1.06) 0.210
Classification of mean skull HU     
 Hypothetical normal Reference   Reference  
 Hypothetical osteopenia 2.90 (0.29–29.30) 0.368 5.67 (0.40–81.37) 0.202
 Hypothetical osteoporosis 3.88 (1.02–14.81) 0.047 5.36 (1.06–27.12) 0.042
  1. PTBE, peritumoral brain edema; LINAC, linear accelerator; GTV, gross tumor volume; BED, biologically equivalent dose; HR, hazard ratio; CI, confidence interval; Gy, gray; HU, Hounsfield unit
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Radiation Oncology

ISSN: 1748-717X

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