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Table 3 Uni- and multivariate Cox regression analyses for the development of PTBE in patients with intracranial meningioma after LINAC-based radiation treatment based on various predictors

From: Effect of osteoporotic conditions on the development of peritumoral brain edema after LINAC-based radiation treatment in patients with intracranial meningioma

 

Univariate analysis

Multivariate analysis

Variable

HR (95% CI)

p

HR (95% CI)

p

Sex

    

 Male

Reference

 

Reference

 

 Female

1.08 (0.30–3.88)

0.905

0.64 (0.15–2.71)

0.543

Age (per 1 year increase)

1.07 (1.02–1.13)

0.005

1.08 (1.01–1.15)

0.032

BMI (per 1 BMI increase)

0.97 (0.82–1.14)

0.722

1.09 (0.88–1.35)

0.419

Classification of mean skull HU

    

 Hypothetical normal

Reference

 

Reference

 

 Hypothetical osteopenia

1.67 (0.17–16.13)

0.657

3.22 (0.23–45.58)

0.387

 Hypothetical osteoporosis

5.45 (1.48–20.03)

0.011

5.20 (1.11–24.46)

0.037

Location

0.70 (0.49–1.00)

0.050

0.70 (0.46–1.06)

0.094

GTV (per 1 cc increase)

1.08 (1.02–1.15)

0.010

1.12 (1.04–1.21)

0.004

BED (α/β = 3) (per 1 Gy increase)

1.01 (0.98–1.03)

0.665

1.02 (0.97–1.06)

0.484

Fractionation (per 1 fraction increase)

0.94 (0.85–1.03)

0.179

0.90 (0.71–1.16)

0.415

Hypertension

    

 No

Reference

 

Reference

 

 Yes

1.13 (0.41–3.15)

0.815

0.66 (0.17–2.61)

0.554

Diabetes

    

 No

Reference

 

Reference

 

 Yes

1.05 (0.29–3.79)

0.937

0.42 (0.09–2.03)

0.278

  1. PTBE, peritumoral brain edema; HR, hazard ratio; CI, confidence interval; BMI, body mass index; HU, Hounsfield unit; GTV, gross tumor volume; BED, biologically equivalent dose; Gy, gray