| |
Univariate analysis
|
Multivariate analysis
|
|---|
|
Variable
|
HR (95% CI)
|
p
|
HR (95% CI)
|
p
|
|---|
|
Sex
| | | | |
|
Male
|
Reference
| |
Reference
| |
|
Female
|
1.08 (0.30–3.88)
|
0.905
|
0.64 (0.15–2.71)
|
0.543
|
|
Age (per 1 year increase)
|
1.07 (1.02–1.13)
|
0.005
|
1.08 (1.01–1.15)
|
0.032
|
|
BMI (per 1 BMI increase)
|
0.97 (0.82–1.14)
|
0.722
|
1.09 (0.88–1.35)
|
0.419
|
|
Classification of mean skull HU
| | | | |
|
Hypothetical normal
|
Reference
| |
Reference
| |
|
Hypothetical osteopenia
|
1.67 (0.17–16.13)
|
0.657
|
3.22 (0.23–45.58)
|
0.387
|
|
Hypothetical osteoporosis
|
5.45 (1.48–20.03)
|
0.011
|
5.20 (1.11–24.46)
|
0.037
|
|
Location
|
0.70 (0.49–1.00)
|
0.050
|
0.70 (0.46–1.06)
|
0.094
|
|
GTV (per 1 cc increase)
|
1.08 (1.02–1.15)
|
0.010
|
1.12 (1.04–1.21)
|
0.004
|
|
BED (α/β = 3) (per 1 Gy increase)
|
1.01 (0.98–1.03)
|
0.665
|
1.02 (0.97–1.06)
|
0.484
|
|
Fractionation (per 1 fraction increase)
|
0.94 (0.85–1.03)
|
0.179
|
0.90 (0.71–1.16)
|
0.415
|
|
Hypertension
| | | | |
|
No
|
Reference
| |
Reference
| |
|
Yes
|
1.13 (0.41–3.15)
|
0.815
|
0.66 (0.17–2.61)
|
0.554
|
|
Diabetes
| | | | |
|
No
|
Reference
| |
Reference
| |
|
Yes
|
1.05 (0.29–3.79)
|
0.937
|
0.42 (0.09–2.03)
|
0.278
|
- PTBE, peritumoral brain edema; HR, hazard ratio; CI, confidence interval; BMI, body mass index; HU, Hounsfield unit; GTV, gross tumor volume; BED, biologically equivalent dose; Gy, gray
