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Table 2 Descriptive information of skull HU values according to the development of PTBE in the study and skull HU values and BMD in the SHUB registry cohorts

From: Effect of osteoporotic conditions on the development of peritumoral brain edema after LINAC-based radiation treatment in patients with intracranial meningioma

Variables Study cohort SHUB registry
PTBE (−) PTBE (+) Total p  
Number 91 15 106   2025
Sex     0.792  
 Female, n (%) 70 (76.9) 12 (80.0) 82 (77.4)   1704 (84.1)
Age, median (IQR), y 61.0 (54.0–72.0) 72.0 (66.0–75.0) 62.5 (54.8–72.0) 0.039 69.0 (59.0–77.0)
Age, mean ± SD, y 62.4 ± 12.2 69.3 ± 9.3 63.3 ± 12.0 0.039 67.9 ± 11.9
Overall mean skull HU value, median (IQR) 730.8 (581.5–874.0) 547.8 (430.5–725.8) 711.6 (547.2–860.7) 0.025 625.7 (483.8–791.5)
Overall mean skull HU value, mean ± SD 737.9 ± 248.9 584.5 ± 189.4 716.2 ± 246.6 0.025 653.0 ± 229.9
Mean HU value at each of four sites in the frontal skull, mean ± SD      
 Right lateral 700.3 ± 238.3 582.5 ± 133.7 683.6 ± 229.7 0.065 598.1 ± 220.4
 Right medial 780.8 ± 287.3 615.5 ± 229.1 757.4 ± 284.8 0.037 704.1 ± 263.6
 Left medial 754.5 ± 283.1 599.5 ± 250.0 732.6 ± 282.8 0.049 698.4 ± 262.4
 Left lateral 716.2 ± 255.2 540.7 ± 178.8 691.3 ± 252.7 0.012 611.5 ± 224.8
 Average, medial 767.7 ± 281.5 607.5 ± 235.2 745.0 ± 280.1 0.040 701.2 ± 257.9
 Average, lateral 708.2 ± 240.1 561.6 ± 153.6 687.5 ± 234.9 0.024 604.8 ± 216.5
Time interval between brain CT and BMD, median (IQR), days N/A N/A N/A   151.0 (9.0–487.0)
T-score, mean ± SD N/A N/A N/A   − 1.99 ± 1.22
 Lumbar spine N/A N/A N/A   − 1.65 ± 1.43
 Femur neck N/A N/A N/A   − 1.40 ± 1.20
BMD categories, n (%)      
 Normal (T-score > − 1.0) N/A N/A N/A   381 (18.8)
 Osteopenia (T-score > − 2.5 and ≤ 1.0) N/A N/A N/A   902 (44.5)
 Osteoporosis (T-score ≤ -2.5) N/A N/A N/A   742 (36.6)
  1. HU, Hounsfield unit; PTBE, peritumoral brain edema; BMD, bone mineral density; SHUB, skull Hounsfield unit and bone mineral density; IQR, interquartile range; SD, standard deviation; CT, computed tomography; N/A, not available